Regulatory Network in Protein Phosphorylation
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Kinase: MNK2 MAP kinase interacting serine/threonine kinase 2

Group: CAMK      Family: MAPKAPK      Subfamily: MNK

Description: MAP kinase interacting serine/threonine kinase 2

Gene Symbol: MKNK2

Synonyms: GPRK7, MNK2

UniprotKB/SwissProt: MKNK2_HUMAN (Q9HBH9)

Function: May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Subcellular Localization:

Protein Domain:
PDB:2AC3

The substrate proteins of kinase MNK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 2Show



The substrate proteins of kinase family MNK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 3Show
2PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show