Regulatory Network in Protein Phosphorylation
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Kinase: TTN titin

Group: CAMK      Family: MLCK      

Description: titin

Gene Symbol: TTN

Synonyms: CMD1G, CMH9, CMPD4, DKFZp451N061, FLJ26020, FLJ26409, FLJ32040, FLJ34413, FLJ39564, FLJ43066, HMERF, LGMD2J, TMD

UniprotKB/SwissProt: TITIN_HUMAN (Q8WZ42)

Function: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Subcellular Localization: Cytoplasm (Probable). Nucleus.

Protein Domain:
PDB:1BPV

The substrate proteins of kinase TTN

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TCAPTELT_HUMANTelethonin (Titin cap protein). 2Show



The substrate proteins of kinase family MLCK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1MRLC2MLRM_HUMANMyosin regulatory light chain 2, nonsarcomeric (Myosin RLC). 1Show
2MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show