|Group: CAMK Family: MLCK |
Description: myosin, light chain kinase
Gene Symbol: MYLK
Synonyms: DKFZp686I10125, FLJ12216, KRP, MLCK, MLCK108, MLCK210, MSTP083
UniprotKB/SwissProt: MYLK_HUMAN (Q15746)
Function: Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis.