Regulatory Network in Protein Phosphorylation
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Kinase: smMLCK myosin, light chain kinase

Group: CAMK      Family: MLCK      

Description: myosin, light chain kinase

Gene Symbol: MYLK

Synonyms: DKFZp686I10125, FLJ12216, KRP, MLCK, MLCK108, MLCK210, MSTP083

UniprotKB/SwissProt: MYLK_HUMAN (Q15746)

Function: Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis.

Subcellular Localization:

Protein Domain:
PDB:2CQV

The substrate proteins of kinase family MLCK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1MRLC2MLRM_HUMANMyosin regulatory light chain 2, nonsarcomeric (Myosin RLC). 1Show
2MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show