Regulatory Network in Protein Phosphorylation
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Kinase: PIM1 pim-1 oncogene

Group: CAMK      Family: PIM      

Description: pim-1 oncogene

Gene Symbol: PIM1

Synonyms: PIM

UniprotKB/SwissProt: PIM1_HUMAN (P11309)

Function: Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3.

Subcellular Localization: Isoform 2: Cytoplasm. Nucleus. Isoform 1: Cell membrane.

Protein Domain:
PDB:1XQZ

The substrate proteins of kinase PIM1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 3Show
2CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
3CDC25AMPIP1_HUMANM-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25A). 2Show
4RP9RP9_HUMANRetinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1). 2Show



The substrate proteins of kinase family PIM

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 9Show
2CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
3CDC25AMPIP1_HUMANM-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25A). 2Show
4RP9RP9_HUMANRetinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1). 2Show