|Group: CAMK Family: RAD53 |
Description: CHK2 checkpoint homolog (S. pombe)
Gene Symbol: CHEK2
Synonyms: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53
UniprotKB/SwissProt: CHK2_HUMAN (O96017)
Function: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
Subcellular Localization: Isoform 2: Nucleus. Note=Isoform 10 is present throughout the cell. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus.