Regulatory Network in Protein Phosphorylation
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Kinase: CHK2 CHK2 checkpoint homolog (S. pombe)

Group: CAMK      Family: RAD53      

Description: CHK2 checkpoint homolog (S. pombe)

Gene Symbol: CHEK2

Synonyms: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53

UniprotKB/SwissProt: CHK2_HUMAN (O96017)

Function: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

Subcellular Localization: Isoform 2: Nucleus. Note=Isoform 10 is present throughout the cell. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus.

Protein Domain:
PDB:1GXC

The substrate proteins of kinase CHK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 3Show
2CHEK2CHK2_HUMANSerine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1). 8Show
3E2F1E2F1_HUMANTranscription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3)(RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associatedprotein 1) (RBAP-1). 2Show
4CDC25AMPIP1_HUMANM-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25A). 11Show
5CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 3Show
6TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show