|Group: CAMK Family: Trbl |
Description: tribbles homolog 3 (Drosophila)
Gene Symbol: TRIB3
Synonyms: C20orf97, NIPK, SINK, SKIP3, TRB3
UniprotKB/SwissProt: TRIB3_HUMAN (Q96RU7)
Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.