Regulatory Network in Protein Phosphorylation
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Kinase: Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Group: CAMK      Family: Trio      

Description: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Gene Symbol: OBSCN

Synonyms: DKFZp666E245, FLJ14124, KIAA1556, MGC120409, MGC120410, MGC120411, MGC120412, MGC138590, UNC89

UniprotKB/SwissProt: OBSCN_HUMAN (Q5VST9)

Function: Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.

Subcellular Localization: Isoform 3: Cytoplasm, myofibril, sarcomere, M-band. Cytoplasm, myofibril, sarcomere, Z-disk. Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z- disk. Isoform 3 colocalizes w

Protein Domain:
PDB:1V1C