Regulatory Network in Protein Phosphorylation
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Kinase: Trad kalirin, RhoGEF kinase

Group: CAMK      Family: Trio      

Description: kalirin, RhoGEF kinase

Gene Symbol: KALRN

Synonyms: DUET, FLJ16443, HAPIP, TRAD, duo

UniprotKB/SwissProt: KALRN_HUMAN (O60229)

Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.

Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.

Protein Domain: