|Group: CAMK Family: Trio |
Description: kalirin, RhoGEF kinase
Gene Symbol: KALRN
Synonyms: DUET, FLJ16443, HAPIP, TRAD, duo
UniprotKB/SwissProt: KALRN_HUMAN (O60229)
Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.