Regulatory Network in Protein Phosphorylation
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Kinase: CK1a casein kinase 1, alpha 1

Group: CK1      Family: CK1      Subfamily: CK1-A

Description: casein kinase 1, alpha 1

Gene Symbol: CSNK1A1

Synonyms: CK1, HLCDGP1, PRO2975

UniprotKB/SwissProt: KC1A_HUMAN (P48729)

Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase CK1a

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1YWHAQ1433T_HUMAN14-3-3 protein theta (14-3-3 protein tau) (14-3-3 protein T-cell)(Protein HS1). 2Show
2YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 2Show
3SLC4A1B3AT_HUMANBand 3 anion transport protein (Anion exchange protein 1) (AE 1)(Solute carrier family 4 member 1) (CD233 antigen). 2Show
4BACE1BACE1_HUMANBeta-secretase 1 precursor (EC (Beta-site APP cleavingenzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1)(Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartylprotease 2) (Asp 2) (ASP2). 1Show
5BIDBID_HUMANBH3-interacting domain death agonist (BID) (p22 BID) [Contains: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domaindeath agonist p13 (p13 BID); BH3-interacting domain death agonist p11(p11 BID)]. 2Show
6CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 2Show
7KCNIP3CSEN_HUMANCalsenilin (Kv channel-interacting protein 3) (KChIP3) (A-typepotassium channel modulatory protein 3) (DRE-antagonist modulator)(DREAM). 1Show
8CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 1Show
9EIF2B5EI2BE_HUMANTranslation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon). 3Show
10FADDFADD_HUMANProtein FADD (FAS-associated death domain protein) (FAS-associatingdeath domain-containing protein) (Mediator of receptor inducedtoxicity). 1Show
11FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 2Show
12HNRNPCHNRPC_HUMANHeterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2). 5Show
13LGALS3LEG3_HUMANGalectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-bindingprotein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35)(Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-bindingprotein) (GALBP). 4Show
14NFATC3NFAC3_HUMANNuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3)(T-cell transcription factor NFAT4) (NF-AT4) (NFATx). 5Show
15TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
16PARK2PRKN2_HUMANE3 ubiquitin-protein ligase parkin (EC 6.3.2.-) (Parkinson juveniledisease protein 2) (Parkinson disease protein 2). 2Show
17PSEN2PSN2_HUMANPresenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5)[Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]. 3Show
18SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show
19SLC18A2VMAT2_HUMANSynaptic vesicular amine transporter (Monoamine transporter)(Vesicular amine transporter 2) (VAT2) (Solute carrier family 18member 2). 1Show