Regulatory Network in Protein Phosphorylation
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Kinase: CK1d casein kinase 1, delta

Group: CK1      Family: CK1      Subfamily: CK1-D

Description: casein kinase 1, delta

Gene Symbol: CSNK1D

Synonyms: HCKID

UniprotKB/SwissProt: KC1D_HUMAN (P48730)

Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase CK1d

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BACE1BACE1_HUMANBeta-secretase 1 precursor (EC (Beta-site APP cleavingenzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1)(Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartylprotease 2) (Asp 2) (ASP2). 2Show
2CDK5CDK5_HUMANCell division protein kinase 5 (EC (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE). 1Show
3CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 1Show
4GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 3Show
5TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
6PER2PER2_HUMANPeriod circadian protein homolog 2 (Circadian clock protein PERIOD 2)(hPER2). 1Show
7PSEN2PSN2_HUMANPresenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5)[Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]. 8Show
8SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show