Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: VRK1 vaccinia related kinase 1

Group: CK1      Family: VRK      

Description: vaccinia related kinase 1

Gene Symbol: VRK1

Synonyms: MGC117401, MGC138280, MGC142070

UniprotKB/SwissProt: VRK1_HUMAN (Q99986)

Function: Serine/threonine kinase that phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2.

Subcellular Localization: Nucleus. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Protein Domain:

The substrate proteins of kinase VRK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 2Show
2JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 2Show
3TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show



The substrate proteins of kinase family VRK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 2Show
2JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 2Show
3TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show