Regulatory Network in Protein Phosphorylation
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Kinase: CDK2 cyclin-dependent kinase 2

Group: CMGC      Family: CDK      Subfamily: CDC2

Description: cyclin-dependent kinase 2

Gene Symbol: CDK2

Synonyms: p33(CDK2)

UniprotKB/SwissProt: CDK2_HUMAN (P24941)

Function: Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase CDK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 3Show
2CABLES1CABL1_HUMANCDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1). 1Show
3CCNE1CCNE1_HUMANG1/S-specific cyclin-E1. 4Show
4CDC6CDC6_HUMANCell division control protein 6 homolog (CDC6-related protein)(p62(cdc6)) (HsCDC6) (HsCDC18). 6Show
5CDK7CDK7_HUMANCell division protein kinase 7 (EC (EC (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complexkinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1). 4Show
6CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
7CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 3Show
8CDX2CDX2_HUMANHomeobox protein CDX-2 (Caudal-type homeobox protein 2) (CDX-3). 4Show
9CEP110CE110_HUMANCentrosomal protein of 110 kDa (Cep110). 8Show
10ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
11FOXM1FOXM1_HUMANForkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocytenuclear factor 3 forkhead homolog 11) (HNF-3/fork-head homolog 11)(HFH-11) (Winged-helix factor from INS-1 cells) (M-phasephosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcriptionfactor Trident). 1Show
12FZR1FZR_HUMANFizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) (hCDH1)(CDC20-like protein 1). 2Show
13HIRAHIRA_HUMANProtein HIRA (TUP1-like enhancer of split protein 1). 4Show
14ID2ID2_HUMANDNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2). 2Show
15ID3ID3_HUMANDNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID-like protein inhibitor HLH 1R21) (Helix-loop-helix protein HEIR-1). 2Show
16PRKAR1AKAP0_HUMANcAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1). 2Show
17TK1KITH_HUMANThymidine kinase, cytosolic (EC 1Show
18MCM4MCM4_HUMANDNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21). 15Show
19MYBL2MYBB_HUMANMyb-related protein B (B-Myb). 22Show
20MYOD1MYOD1_HUMANMyoblast determination protein 1 (Myogenic factor 3) (Myf-3). 1Show
21NPATNPAT_HUMANProtein NPAT (Nuclear protein of the ataxia telangiectasia mutatedlocus) (Nuclear protein of the ATM locus) (p220). 5Show
22NPM1NPM_HUMANNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38). 1Show
23ORC1LORC1_HUMANOrigin recognition complex subunit 1 (Replication control protein 1). 3Show
24TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
25TP73P73_HUMANTumor protein p73 (p53-like transcription factor) (p53-relatedprotein). 2Show
26COILP80C_HUMANCoilin (p80). 2Show
27PPP1CAPP1A_HUMANSerine/threonine-protein phosphatase PP1-alpha catalytic subunit(EC (PP-1A). 1Show
28PRC1PRC1_HUMANProtein regulator of cytokinesis 1. 3Show
29PGRPRGR_HUMANProgesterone receptor (PR) (Nuclear receptor subfamily 3 group Cmember 3). 8Show
30PTHLHPTHR_HUMANParathyroid hormone-related protein precursor (PTH-rP) (PTHrP)[Contains: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]. 1Show
31RBL1RBL1_HUMANRetinoblastoma-like protein 1 (107 kDa retinoblastoma-associatedprotein) (p107) (PRB1). 9Show
32RBL2RBL2_HUMANRetinoblastoma-like protein 2 (130 kDa retinoblastoma-associatedprotein) (p130) (PRB2) (RBR-2). 15Show
33RB1RB_HUMANRetinoblastoma-associated protein (PP110) (P105-RB) (RB). 5Show
34SF3B1SF3B1_HUMANSplicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit). 3Show
35SMAD3SMAD3_HUMANMothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3). 8Show
36TFDP1TFDP1_HUMANTranscription factor Dp-1 (E2F dimerization partner 1) (DRTF1-polypeptide 1) (DRTF1). 1Show
37TFDP2TFDP2_HUMANTranscription factor Dp-2 (E2F dimerization partner 2). 2Show
38UBE2AUBE2A_HUMANUbiquitin-conjugating enzyme E2 A (EC (Ubiquitin-proteinligase A) (Ubiquitin carrier protein A) (HR6A) (hHR6A). 2Show
39UBTFUBF1_HUMANNucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1)(Autoantigen NOR-90). 3Show

The substrate proteins of kinase family CDC2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 2Show
2ABL1ABL1_HUMANProto-oncogene tyrosine-protein kinase ABL1 (EC (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1). 1Show
3AMPHAMPH_HUMANAmphiphysin. 3Show
4ANAPC1ANC1_HUMANAnaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1)(Testis-specific gene 24 protein) (Mitotic checkpoint regulator). 11Show
5ANAPC4ANC4_HUMANAnaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4). 1Show
6APLP2APLP2_HUMANAmyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)(CDEI box-binding protein) (CDEBP). 2Show
7BIRC5BIRC5_HUMANBaculoviral IAP repeat-containing protein 5 (Apoptosis inhibitorsurvivin) (Apoptosis inhibitor 4). 3Show
8BUB1BUB1_HUMANMitotic checkpoint serine/threonine-protein kinase BUB1 (EC (BUB1A). 1Show
9CALD1CALD1_HUMANCaldesmon (CDM). 13Show
10CDC16CDC16_HUMANCell division cycle protein 16 homolog (CDC16Hs) (Anaphase-promotingcomplex subunit 6) (APC6) (Cyclosome subunit 6). 2Show
11CDC23CDC23_HUMANCell division cycle protein 23 homolog (Anaphase-promoting complexsubunit 8) (APC8) (Cyclosome subunit 8). 3Show
12CDC27CDC27_HUMANCell division cycle protein 27 homolog (CDC27Hs) (H-NUC). 11Show
13CDK7CDK7_HUMANCell division protein kinase 7 (EC (EC (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complexkinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1). 4Show
14CEP55CEP55_HUMANCentrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer6). 4Show
15NCAPD2CND1_HUMANCondensin complex subunit 1 (Non-SMC condensin I complex subunit D2)(Chromosome condensation-related SMC-associated protein 1)(Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog). 3Show
16CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 2Show
17CSNK2A1CSK21_HUMANCasein kinase II subunit alpha (EC (CK II). 8Show
18CSNK2BCSK2B_HUMANCasein kinase II subunit beta (CK II beta) (Phosvitin) (G5a). 2Show
19CUTL1CUTL1_HUMANHomeobox protein cut-like 1 (CCAAT displacement protein) (CDP). 4Show
20DDX3XDDX3X_HUMANATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X-chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform). 2Show
21DLG7DLG7_HUMANDisks large-associated protein DLG7 (Discs large homolog 7) (Hepatomaup-regulated protein) (HURP). 9Show
22DUTDUT_HUMANDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialprecursor (EC (dUTPase) (dUTP pyrophosphatase). 1Show
23E2F1E2F1_HUMANTranscription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3)(RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associatedprotein 1) (RBAP-1). 4Show
24ECT2ECT2_HUMANProtein ECT2 (Epithelial cell-transforming sequence 2 oncogene). 4Show
25EEF1DEF1D_HUMANElongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4). 1Show
26EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC (Receptortyrosine-protein kinase ErbB-1). 1Show
27EPN1EPN1_HUMANEpsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitoticphosphoprotein). 3Show
28ESPL1ESPL1_HUMANSeparin (EC (Separase) (Caspase-like protein ESPL1) (Extraspindle poles-like 1 protein). 1Show
29FANCGFANCG_HUMANFanconi anemia group G protein (Protein FACG) (DNA-repair proteinXRCC9). 1Show
30FEN1FEN1_HUMANFlap endonuclease 1 (EC 3.1.-.-) (Flap structure-specific endonuclease1) (FEN-1) (Maturation factor 1) (MF1) (hFEN-1) (DNase IV). 2Show
31FOXM1FOXM1_HUMANForkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocytenuclear factor 3 forkhead homolog 11) (HNF-3/fork-head homolog 11)(HFH-11) (Winged-helix factor from INS-1 cells) (M-phasephosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcriptionfactor Trident). 1Show
32GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 2Show
33GOLGA2GOGA2_HUMANGolgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130autoantigen) (Golgin-95). 2Show
34HIST1H1AH11_HUMANHistone H1.1. 4Show
35HMGA1HMGA1_HUMANHigh mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobilitygroup AT-hook protein 1) (High mobility group protein A1) (Highmobility group protein-R). 4Show
36HMGA2HMGA2_HUMANHigh mobility group protein HMGI-C (High mobility group AT-hookprotein 2). 4Show
37IL16IL16_HUMANInterleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor)(LCF). 1Show
38ITPR1ITPR1_HUMANInositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform1) (InsP3R1) (IP3R). 3Show
39KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 3Show
40KRT8K2C8_HUMANKeratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8)(K8). 1Show
41KHDRBS1KHDR1_HUMANKH domain-containing, RNA-binding, signal transduction-associatedprotein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68kDa protein) (Sam68) (p68). 2Show
42KIF11KIF11_HUMANKinesin-like protein KIF11 (Kinesin-related motor protein Eg5)(Kinesin-like spindle protein HKSP) (Thyroid receptor-interactingprotein 5) (TRIP-5) (Kinesin-like protein 1). 3Show
43KIF22KIF22_HUMANKinesin-like protein KIF22 (Kinesin-like DNA-binding protein)(Kinesin-like protein 4). 1Show
44TK1KITH_HUMANThymidine kinase, cytosolic (EC 2Show
45RPS6KB1KS6B1_HUMANRibosomal protein S6 kinase beta-1 (EC (Ribosomal protein S6kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha). 6Show
46LATS1LATS1_HUMANSerine/threonine-protein kinase LATS1 (EC (Large tumorsuppressor homolog 1) (WARTS protein kinase) (h-warts). 2Show
47LBRLBR_HUMANLamin-B receptor (Integral nuclear envelope inner membrane protein)(LMN2R). 1Show
48LMNALMNA_HUMANLamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32). 3Show
49LMNB1LMNB1_HUMANLamin-B1. 1Show
50MAP4MAP4_HUMANMicrotubule-associated protein 4 (MAP 4). 5Show
51MCM4MCM4_HUMANDNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21). 5Show
52MEF2CMEF2C_HUMANMyocyte-specific enhancer factor 2C. 1Show
53CDC25AMPIP1_HUMANM-phase inducer phosphatase 1 (EC (Dual specificityphosphatase Cdc25A). 4Show
54CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC (Dual specificityphosphatase Cdc25B). 2Show
55CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC (Dual specificityphosphatase Cdc25C). 12Show
56MPHOSPH1MPPH1_HUMANM-phase phosphoprotein 1 (MPP1) (Kinesin-related motor interactingwith PIN1) (Cancer/testis antigen 90) (CT90). 3Show
57MYOD1MYOD1_HUMANMyoblast determination protein 1 (Myogenic factor 3) (Myf-3). 2Show
58NDE1NDE1_HUMANNuclear distribution protein nudE homolog 1 (NudE). 2Show
59NDEL1NDEL1_HUMANNuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1). 3Show
60NESNEST_HUMANNestin. 1Show
61NPM1NPM_HUMANNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38). 6Show
62NSFL1CNSF1C_HUMANNSFL1 cofactor p47 (p97 cofactor p47). 5Show
63ORC1LORC1_HUMANOrigin recognition complex subunit 1 (Replication control protein 1). 3Show
64PIK3C2AP3C2A_HUMANPhosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alphapolypeptide (EC (Phosphoinositide 3-Kinase-C2-alpha)(PtdIns-3-kinase C2 alpha) (PI3K-C2alpha). 1Show
65TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
66TP73P73_HUMANTumor protein p73 (p53-like transcription factor) (p53-relatedprotein). 1Show
67PITPNM1PITM1_HUMANMembrane-associated phosphatidylinositol transfer protein 1(Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinaldegeneration B homolog). 4Show
68PLEC1PLEC1_HUMANPlectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1) (Plectin-11). 4Show
69NUP210PO210_HUMANNuclear pore membrane glycoprotein 210 precursor (POM210) (Nuclearpore protein gp210). 1Show
70PPP1CAPP1A_HUMANSerine/threonine-protein phosphatase PP1-alpha catalytic subunit(EC (PP-1A). 1Show
71PRDX1PRDX1_HUMANPeroxiredoxin-1 (EC (Thioredoxin peroxidase 2)(Thioredoxin-dependent peroxide reductase 2) (Proliferation-associatedgene protein) (PAG) (Natural killer cell-enhancing factor A) (NKEF-A). 2Show
72PTHLHPTHR_HUMANParathyroid hormone-related protein precursor (PTH-rP) (PTHrP)[Contains: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]. 1Show
73PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC phosphatase 1B) (PTP-1B). 3Show
74PTTG1PTTG1_HUMANSecurin (Pituitary tumor-transforming protein 1) (Tumor-transformingprotein 1) (Esp1-associated protein) (hPTTG). 3Show
75Q6VVE6_HUMANNeural interleukin 16 protein. 1Show
76RAB1ARAB1A_HUMANRas-related protein Rab-1A (YPT1-related protein). 1Show
77RAB4ARAB4A_HUMANRas-related protein Rab-4A. 2Show
78RAB5BRAB5B_HUMANRas-related protein Rab-5B. 2Show
79RBBP5RBBP5_HUMANRetinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-bindingprotein RBQ-3). 2Show
80RB1RB_HUMANRetinoblastoma-associated protein (PP110) (P105-RB) (RB). 10Show
81RCC1RCC1_HUMANRegulator of chromosome condensation (Chromosome condensation protein1) (Cell cycle regulatory protein). 1Show
82RPA2RFA2_HUMANReplication protein A 32 kDa subunit (RP-A) (RF-A) (Replicationfactor-A protein 2) (p32) (p34). 5Show
83RGC32RGC32_HUMANResponse gene to complement 32 protein (RGC-32). 1Show
84RRM2RIR2_HUMANRibonucleoside-diphosphate reductase subunit M2 (EC reductase small subunit) (Ribonucleotide reductasesmall chain). 2Show
85RAP1GAPRPGP1_HUMANRap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP). 2Show
86SLBPSLBP_HUMANHistone RNA hairpin-binding protein (Histone stem-loop-bindingprotein). 1Show
87STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 6Show
88STMN2STMN2_HUMANStathmin-2 (Protein SCG10) (Superior cervical ganglion-10 protein). 1Show
89SYN3SYN3_HUMANSynapsin-3 (Synapsin III). 1Show
90MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 2Show
91HTATIPTIP60_HUMANHistone acetyltransferase HTATIP (EC (EC 2.3.1.-) (60 kDaTat interactive protein) (Tip60) (HIV-1 Tat interactive protein)(cPLA(2)-interacting protein). 5Show
92TLE1TLE1_HUMANTransducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog). 3Show
93TLE2TLE2_HUMANTransducin-like enhancer protein 2 (ESG2). 2Show
94TLE4TLE4_HUMANTransducin-like enhancer protein 4. 1Show
95TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC (DNA topoisomerase II, alphaisozyme). 10Show
96PBKTOPK_HUMANLymphokine-activated killer T-cell-originated protein kinase(EC (T-LAK cell-originated protein kinase) (PDZ-bindingkinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-likeprotein kinase) (Nori-3) (Cancer/testis antigen 84) (CT84). 2Show
97TSC1TSC1_HUMANHamartin (Tuberous sclerosis 1 protein). 6Show
98UBA1UBA1_HUMANUbiquitin-like modifier-activating enzyme 1 (Ubiquitin-activatingenzyme E1) (Protein A1S9). 4Show
99UBE2AUBE2A_HUMANUbiquitin-conjugating enzyme E2 A (EC (Ubiquitin-proteinligase A) (Ubiquitin carrier protein A) (HR6A) (hHR6A). 2Show
100VIMVIME_HUMANVimentin. 2Show
101WEE1WEE1_HUMANWee1-like protein kinase (EC (Wee1A kinase) (WEE1hu). 2Show