Regulatory Network in Protein Phosphorylation
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Kinase: CDK5 cyclin-dependent kinase 5

Group: CMGC      Family: CDK      Subfamily: CDK5

Description: cyclin-dependent kinase 5

Gene Symbol: CDK5

Synonyms: PSSALRE

UniprotKB/SwissProt: CDK5_HUMAN (Q00535)

Function: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.

Subcellular Localization: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity).

Protein Domain:
PDB:1H4L

The substrate proteins of kinase CDK5

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 2Show
2AMPHAMPH_HUMANAmphiphysin. 3Show
3DAB1DAB1_HUMANDisabled homolog 1. 3Show
4DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 9Show
5DNM1DYN1_HUMANDynamin-1 (EC 3.6.5.5). 2Show
6ERBB3ERBB3_HUMANReceptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3). 2Show
7VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
8PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 2Show
9MEF2AMEF2A_HUMANMyocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1). 2Show
10MEF2DMEF2D_HUMANMyocyte-specific enhancer factor 2D. 1Show
11MAPK10MK10_HUMANMitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p493F12). 1Show
12MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 1Show
13NDEL1NDEL1_HUMANNuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1). 5Show
14NESNEST_HUMANNestin. 2Show
15GRIN2ANMDE1_HUMANGlutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A). 1Show
16TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
17PAK1PAK1_HUMANSerine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activatedkinase 1) (PAK-1) (p65-PAK) (Alpha-PAK). 1Show
18PCTK1PCTK1_HUMANSerine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE-motif protein kinase 1). 1Show
19PPP1R1BPPR1B_HUMANProtein phosphatase 1 regulatory subunit 1B (Dopamine- and cAMP-regulated neuronal phosphoprotein) (DARPP-32). 2Show
20PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 2Show
21RASGRF2RGRF2_HUMANRas-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Guaninenucleotide-releasing factor 2) (Ras guanine nucleotide exchange factor2). 1Show
22SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src). 2Show
23SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 8Show
24MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 24Show



The substrate proteins of kinase family CDK5

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 2Show
2AMPHAMPH_HUMANAmphiphysin. 3Show
3DAB1DAB1_HUMANDisabled homolog 1. 3Show
4DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 9Show
5DNM1DYN1_HUMANDynamin-1 (EC 3.6.5.5). 2Show
6ERBB3ERBB3_HUMANReceptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3). 2Show
7VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
8PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 2Show
9MEF2AMEF2A_HUMANMyocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1). 2Show
10MEF2DMEF2D_HUMANMyocyte-specific enhancer factor 2D. 1Show
11MAPK10MK10_HUMANMitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p493F12). 1Show
12MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 1Show
13NDEL1NDEL1_HUMANNuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1). 5Show
14NESNEST_HUMANNestin. 2Show
15GRIN2ANMDE1_HUMANGlutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A). 1Show
16TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
17PAK1PAK1_HUMANSerine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activatedkinase 1) (PAK-1) (p65-PAK) (Alpha-PAK). 1Show
18PCTK1PCTK1_HUMANSerine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE-motif protein kinase 1). 1Show
19PPP1R1BPPR1B_HUMANProtein phosphatase 1 regulatory subunit 1B (Dopamine- and cAMP-regulated neuronal phosphoprotein) (DARPP-32). 2Show
20PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 2Show
21RASGRF2RGRF2_HUMANRas-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Guaninenucleotide-releasing factor 2) (Ras guanine nucleotide exchange factor2). 1Show
22SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src). 2Show
23SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 8Show
24MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 24Show