Regulatory Network in Protein Phosphorylation
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Kinase: CDK9 cyclin-dependent kinase 9 (CDC2-related kinase)

Group: CMGC      Family: CDK      Subfamily: CDK9

Description: cyclin-dependent kinase 9 (CDC2-related kinase)

Gene Symbol: CDK9

Synonyms: C-2k, CDC2L4, PITALRE, TAK

UniprotKB/SwissProt: CDK9_HUMAN (P50750)

Function: Member of the cyclin-dependent kinase pair (CDK9/cyclin- T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.

Subcellular Localization: Nucleus.

Protein Domain:
PDB:1PF6

The substrate proteins of kinase CDK9

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 3Show
2POLR2ARPB1_HUMANDNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6) (RNApolymerase II subunit B1) (DNA-directed RNA polymerase II subunit A)(DNA-directed RNA polymerase III largest subunit). 1Show
3SUPT5HSPT5H_HUMANTranscription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducingfactor large subunit) (DSIF large subunit) (DSIF p160) (Tat-cotransactivator 1 protein) (Tat-CT1 protein). 2Show



The substrate proteins of kinase family CDK9

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 3Show
2POLR2ARPB1_HUMANDNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6) (RNApolymerase II subunit B1) (DNA-directed RNA polymerase II subunit A)(DNA-directed RNA polymerase III largest subunit). 1Show
3SUPT5HSPT5H_HUMANTranscription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducingfactor large subunit) (DSIF large subunit) (DSIF p160) (Tat-cotransactivator 1 protein) (Tat-CT1 protein). 2Show