|Group: CMGC Family: CDK Subfamily: CDK9|
Description: cyclin-dependent kinase 9 (CDC2-related kinase)
Gene Symbol: CDK9
Synonyms: C-2k, CDC2L4, PITALRE, TAK
UniprotKB/SwissProt: CDK9_HUMAN (P50750)
Function: Member of the cyclin-dependent kinase pair (CDK9/cyclin- T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
Subcellular Localization: Nucleus.