Regulatory Network in Protein Phosphorylation
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Kinase: CDK6 cyclin-dependent kinase 6

Group: CMGC      Family: CDK      Subfamily: CDK4

Description: cyclin-dependent kinase 6

Gene Symbol: CDK6

Synonyms: MGC59692, PLSTIRE

UniprotKB/SwissProt: CDK6_HUMAN (Q00534)

Function: Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.

Subcellular Localization:

Protein Domain:
PDB:1BI7

The substrate proteins of kinase CDK6

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 1Show
2RBL2RBL2_HUMANRetinoblastoma-like protein 2 (130 kDa retinoblastoma-associatedprotein) (p130) (PRB2) (RBR-2). 3Show



The substrate proteins of kinase family CDK4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1RBL1RBL1_HUMANRetinoblastoma-like protein 1 (107 kDa retinoblastoma-associatedprotein) (p107) (PRB1). 12Show
2RBL2RBL2_HUMANRetinoblastoma-like protein 2 (130 kDa retinoblastoma-associatedprotein) (p130) (PRB2) (RBR-2). 3Show
3RB1RB_HUMANRetinoblastoma-associated protein (PP110) (P105-RB) (RB). 6Show
4SMAD3SMAD3_HUMANMothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3). 8Show
5UBTFUBF1_HUMANNucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1)(Autoantigen NOR-90). 1Show