Regulatory Network in Protein Phosphorylation
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Kinase: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)

Group: CMGC      Family: CDK      Subfamily: CDK7

Description: cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)

Gene Symbol: CDK7

Synonyms: CAK1, CDKN7, STK1, p39MO15

UniprotKB/SwissProt: CDK7_HUMAN (P50613)

Function: Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Subcellular Localization: Nucleus.

Protein Domain:
PDB:1LG3

The substrate proteins of kinase CDK7

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 2Show
2CDK2CDK2_HUMANCell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase). 1Show
3CDK4CDK4_HUMANCell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase4) (PSK-J3). 1Show
4CDK7CDK7_HUMANCell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complexkinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1). 2Show
5E2F1E2F1_HUMANTranscription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3)(RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associatedprotein 1) (RBAP-1). 4Show
6ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
7ICKICK_HUMANSerine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cellkinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2)(LCK2). 1Show
8LASP1LASP1_HUMANLIM and SH3 domain protein 1 (LASP-1) (MLN 50). 2Show
9TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 5Show
10PCGF6PCGF6_HUMANPolycomb group RING finger protein 6 (RING finger protein 134) (Mel18and Bmi1-like RING finger). 1Show
11POU2F1PO2F1_HUMANPOU domain, class 2, transcription factor 1 (Octamer-bindingtranscription factor 1) (Oct-1) (OTF-1) (NF-A1). 1Show
12RARARARA_HUMANRetinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1group B member 1). 2Show



The substrate proteins of kinase family CDK7

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 2Show
2CDK2CDK2_HUMANCell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase). 1Show
3CDK4CDK4_HUMANCell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase4) (PSK-J3). 1Show
4CDK7CDK7_HUMANCell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complexkinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1). 2Show
5E2F1E2F1_HUMANTranscription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3)(RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associatedprotein 1) (RBAP-1). 4Show
6ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
7ICKICK_HUMANSerine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cellkinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2)(LCK2). 1Show
8LASP1LASP1_HUMANLIM and SH3 domain protein 1 (LASP-1) (MLN 50). 2Show
9TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 5Show
10PCGF6PCGF6_HUMANPolycomb group RING finger protein 6 (RING finger protein 134) (Mel18and Bmi1-like RING finger). 1Show
11POU2F1PO2F1_HUMANPOU domain, class 2, transcription factor 1 (Octamer-bindingtranscription factor 1) (Oct-1) (OTF-1) (NF-A1). 1Show
12RARARARA_HUMANRetinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1group B member 1). 2Show