Regulatory Network in Protein Phosphorylation
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Kinase: CK2a2 casein kinase 2, alpha prime polypeptide

Group: CMGC      Family: CK2      

Description: casein kinase 2, alpha prime polypeptide

Gene Symbol: CSNK2A2

Synonyms: CK2A2, CSNK2A1, FLJ43934

UniprotKB/SwissProt: CSK22_HUMAN (P19784)

Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase CK2a2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 1Show
2ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 2Show
3AQP4AQP4_HUMANAquaporin-4 (AQP-4) (WCH4) (Mercurial-insensitive water channel)(MIWC). 3Show
4ARRB2ARRB2_HUMANBeta-arrestin-2 (Arrestin beta 2). 1Show
5BIDBID_HUMANBH3-interacting domain death agonist (BID) (p22 BID) [Contains: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domaindeath agonist p13 (p13 BID); BH3-interacting domain death agonist p11(p11 BID)]. 2Show
6CAV1CAV1_HUMANCaveolin-1. 1Show
7MS4A1CD20_HUMANB-lymphocyte antigen CD20 (Membrane-spanning 4-domains subfamily Amember 1) (B-lymphocyte surface antigen B1) (Leu-16) (Bp35). 3Show
8PTPRCCD45_HUMANLeukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45antigen). 4Show
9CDC37CDC37_HUMANHsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targetingsubunit) (p50Cdc37). 1Show
10CLTBCLCB_HUMANClathrin light chain B (Lcb). 2Show
11CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 2Show
12CTDP1CTDP1_HUMANRNA polymerase II subunit A C-terminal domain phosphatase(EC 3.1.3.16) (TFIIF-associating CTD phosphatase). 2Show
13EEF1B2EF1B_HUMANElongation factor 1-beta (EF-1-beta). 2Show
14EIF2B5EI2BE_HUMANTranslation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon). 2Show
15HDAC1HDAC1_HUMANHistone deacetylase 1 (HD1). 2Show
16HDAC2HDAC2_HUMANHistone deacetylase 2 (HD2). 3Show
17HMGA1HMGA1_HUMANHigh mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobilitygroup AT-hook protein 1) (High mobility group protein A1) (Highmobility group protein-R). 3Show
18HNRNPCHNRPC_HUMANHeterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2). 1Show
19HSPH1HS105_HUMANHeat shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY-CO-25). 1Show
20IL16IL16_HUMANInterleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor)(LCF). 1Show
21PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 3Show
22KIF1CKIF1C_HUMANKinesin-like protein KIF1C. 1Show
23LGALS3LEG3_HUMANGalectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-bindingprotein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35)(Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-bindingprotein) (GALBP). 2Show
24MYCNMYCN_HUMANN-myc proto-oncogene protein. 2Show
25MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 1Show
26MYF5MYF5_HUMANMyogenic factor 5 (Myf-5). 2Show
27SPP1OSTP_HUMANOsteopontin precursor (Bone sialoprotein 1) (Secreted phosphoprotein1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin). 1Show
28PIN4PIN4_HUMANPeptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8)(Rotamase Pin4) (PPIase Pin4) (Parvulin 14) (Par14) (Peptidyl-prolylcis/trans isomerase EPVH) (hPar14). 1Show
29PPP1R8PP1R8_HUMANNuclear inhibitor of protein phosphatase 1 (NIPP-1) (Proteinphosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator ofRNA decay (EC 3.1.4.-) (ARD-1)]. 2Show
30PPP1R1BPPR1B_HUMANProtein phosphatase 1 regulatory subunit 1B (Dopamine- and cAMP-regulated neuronal phosphoprotein) (DARPP-32). 3Show
31PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
32PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 3Show
33RGS19RGS19_HUMANRegulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP). 1Show
34SAT1SAT1_HUMANDiamine acetyltransferase 1 (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) (Putrescine acetyltransferase)(Polyamine N-acetyltransferase 1). 3Show
35SPIBSPIB_HUMANTranscription factor Spi-B. 4Show
36STX1ASTX1A_HUMANSyntaxin-1A (Neuron-specific antigen HPC-1). 1Show
37SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show
38GTF2A1TF2AA_HUMANTranscription initiation factor IIA subunit 1 (General transcriptionfactor IIA1) (TFIIA-42) (TFIIAL) [Contains: Transcription initiationfactor IIA alpha chain (TFIIA p35 subunit); Transcription initiationfactor IIA beta chain (TFIIA p19 subunit)]. 4Show
39GTF2A1LTF2AY_HUMANTFIIA-alpha and beta-like factor (General transcription factor II A,1-like factor). 4Show
40TCF7L2TF7L2_HUMANTranscription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (TCF-4) (hTCF-4). 3Show
41UBE2R2UB2R2_HUMANUbiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-proteinligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). 1Show
42SLC18A2VMAT2_HUMANSynaptic vesicular amine transporter (Monoamine transporter)(Vesicular amine transporter 2) (VAT2) (Solute carrier family 18member 2). 1Show
43WASWASP_HUMANWiskott-Aldrich syndrome protein (WASp). 2Show
44XRCC1XRCC1_HUMANDNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1). 3Show



The substrate proteins of kinase family CK2

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
2APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 1Show
3ABCA1ABCA1_HUMANATP-binding cassette sub-family A member 1 (ATP-binding cassettetransporter 1) (ATP-binding cassette 1) (ABC-1) (Cholesterol effluxregulatory protein). 3Show
4ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 7Show
5ACCN3ACCN3_HUMANAmiloride-sensitive cation channel 3 (Acid-sensing ion channel 3)(ASIC3) (hASIC3) (Testis sodium channel 1) (hTNaC1). 2Show
6AIPAIP_HUMANAH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (Immunophilin homolog ARA9) (HBV X-associatedprotein 2) (XAP-2). 2Show
7AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 1Show
8ANP32AAN32A_HUMANAcidic leucine-rich nuclear phosphoprotein 32 family member A (Potentheat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclearphosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp)(Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin). 2Show
9APEX1