Regulatory Network in Protein Phosphorylation
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Kinase: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Group: CMGC      Family: DYRK      Subfamily: DYRK1

Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Gene Symbol: DYRK1B

Synonyms: MIRK

UniprotKB/SwissProt: DYR1B_HUMAN (Q9Y463)

Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.

Subcellular Localization: Nucleus.

Protein Domain:

The substrate proteins of kinase DYRK1B

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
2DYRK1BDYR1B_HUMANDual specificity tyrosine-phosphorylation-regulated kinase 1B(EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase). 4Show
3HNF1AHNF1A_HUMANHepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specifictranscription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1). 1Show



The substrate proteins of kinase family DYRK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CCNL2CCNL2_HUMANCyclin-L2 (Paneth cell-enhanced expression protein). 3Show
2CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
3DNM1DYN1_HUMANDynamin-1 (EC 3.6.5.5). 1Show
4DYRK1ADYR1A_HUMANDual specificity tyrosine-phosphorylation-regulated kinase 1A(EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dualspecificity YAK1-related kinase) (hMNB). 2Show
5DYRK1BDYR1B_HUMANDual specificity tyrosine-phosphorylation-regulated kinase 1B(EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase). 4Show
6FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 4Show
7HNF1AHNF1A_HUMANHepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specifictranscription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1). 1Show
8SF3B1SF3B1_HUMANSplicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit). 1Show