Regulatory Network in Protein Phosphorylation
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Kinase: DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Group: CMGC      Family: DYRK      Subfamily: DYRK2

Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Gene Symbol: DYRK2

Synonyms: -

UniprotKB/SwissProt: DYRK2_HUMAN (Q92630)

Function: Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Subcellular Localization: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.

Protein Domain:

The substrate proteins of kinase DYRK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1DPYSL3Q6DEN2_HUMANDPYSL3 protein. 1Show



The substrate proteins of kinase family DYRK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1DPYSL3Q6DEN2_HUMANDPYSL3 protein. 1Show