Regulatory Network in Protein Phosphorylation
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Kinase: HIPK1 homeodomain interacting protein kinase 1

Group: CMGC      Family: DYRK      Subfamily: HIPK

Description: homeodomain interacting protein kinase 1

Gene Symbol: HIPK1

Synonyms: KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2

UniprotKB/SwissProt: HIPK1_HUMAN (Q86Z02)

Function: May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.

Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.

Protein Domain:

The substrate proteins of kinase family HIPK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CTBP1CTBP1_HUMANC-terminal-binding protein 1 (EC 1.1.1.-) (CtBP1). 1Show
2FADDFADD_HUMANProtein FADD (FAS-associated death domain protein) (FAS-associatingdeath domain-containing protein) (Mediator of receptor inducedtoxicity). 2Show
3TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 3Show