Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: HIPK2 homeodomain interacting protein kinase 2

Group: CMGC      Family: DYRK      Subfamily: HIPK

Description: homeodomain interacting protein kinase 2

Gene Symbol: HIPK2

Synonyms: PRO0593

UniprotKB/SwissProt: HIPK2_HUMAN (Q9H2X6)

Function: Protein kinase acting as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. Phosphorylation of TP53 may be mediated by a TP53-HIPK2-AXIN1 complex. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB (By similarity). Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity.

Subcellular Localization: Nucleus. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic.

Protein Domain:

The substrate proteins of kinase HIPK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CTBP1CTBP1_HUMANC-terminal-binding protein 1 (EC 1.1.1.-) (CtBP1). 1Show
2TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 3Show



The substrate proteins of kinase family HIPK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CTBP1CTBP1_HUMANC-terminal-binding protein 1 (EC 1.1.1.-) (CtBP1). 1Show
2FADDFADD_HUMANProtein FADD (FAS-associated death domain protein) (FAS-associatingdeath domain-containing protein) (Mediator of receptor inducedtoxicity). 2Show
3TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 3Show