Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: GSK3A glycogen synthase kinase 3 alpha

Group: CMGC      Family: GSK      

Description: glycogen synthase kinase 3 alpha

Gene Symbol: GSK3A

Synonyms: DKFZp686D0638

UniprotKB/SwissProt: GSK3A_HUMAN (P49840)

Function: Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).

Subcellular Localization:

Protein Domain:
PDB:2DFM

The substrate proteins of kinase GSK3A

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CCNE1CCNE1_HUMANG1/S-specific cyclin-E1. 1Show
2CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 1Show
3EIF2B5EI2BE_HUMANTranslation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon). 2Show
4HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 1Show
5JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 2Show
6MCL1MCL1_HUMANInduced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) (mcl1/EAT). 2Show
7MKI67IPMK67I_HUMANMKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolarprotein interacting with the FHA domain of pKI-67) (hNIFK) (Nucleolarphosphoprotein Nopp34). 2Show
8MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 1Show
9MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 2Show



The substrate proteins of kinase family GSK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 2Show
2ACLYACLY_HUMANATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme). 4Show
3CABYRCABYR_HUMANCalcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Testis-specific calcium-binding protein CBP86)(Fibrousheathin-2) (FSP-2) (Fibrousheathin II) (Cancer/testis antigen88) (CT88). 2Show
4CDH1CADH1_HUMANEpithelial cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1)(CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. 1Show
5CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 2Show
6CCND3CCND3_HUMANG1/S-specific cyclin-D3. 1Show
7CCNE1CCNE1_HUMANG1/S-specific cyclin-E1. 4Show
8CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
9CDX2CDX2_HUMANHomeobox protein CDX-2 (Caudal-type homeobox protein 2) (CDX-3). 4Show
10CEBPACEBPA_HUMANCCAAT/enhancer-binding protein alpha (C/EBP alpha). 2Show
11CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
12CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 2Show
13CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 11Show
14CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 2Show
15DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 3Show
16EIF2B5EI2BE_HUMANTranslation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon). 6Show
17ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 4Show
18FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 2Show
19GYS1GYS1_HUMANGlycogen [starch] synthase, muscle (EC 2.4.1.11). 7Show
20HNRPDHNRPD_HUMANHeterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich elementRNA-binding protein 1). 2Show
21HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 2Show
22PPP1R2P1IPP2L_HUMANProtein phosphatase inhibitor 2-like protein 1 (Protein phosphatase 1,regulatory subunit 2 pseudogene 1). 1Show
23PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 3Show
24JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 2Show
25MCL1MCL1_HUMANInduced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) (mcl1/EAT). 4Show
26MITFMITF_HUMANMicrophthalmia-associated transcription factor. 3Show
27MKI67IPMK67I_HUMANMKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolarprotein interacting with the FHA domain of pKI-67) (hNIFK) (Nucleolarphosphoprotein Nopp34). 2Show
28MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 3Show
29MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 2Show
30MYLKMYLK_HUMANMyosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK)(Telokin) (Kinase-related protein) (KRP). 1Show
31NACANACA_HUMANNascent polypeptide-associated complex subunit alpha (NAC-alpha)(Alpha-NAC) (Hom s 2.02). 2Show
32NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 5Show
33NOTCH2NOTC2_HUMANNeurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)[Contains: Notch 2 extracellular truncation; Notch 2 intracellulardomain]. 4Show
34TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
35PPP1R3APPR3A_HUMANProtein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1glycogen-associated regulatory subunit) (Protein phosphatase type-1glycogen targeting subunit). 2Show
36PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 4Show
37PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
38DPYSL3Q6DEN2_HUMANDPYSL3 protein. 3Show
39RCAN1RCAN1_HUMANCalcipressin-1 (Regulator of calcineurin 1) (Down syndrome criticalregion protein 1) (Myocyte-enriched calcineurin-interacting protein 1)(MCIP1) (Adapt78). 3Show
40RAP1GAPRPGP1_HUMANRap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP). 1Show
41SNAI1SNAI_HUMANZinc finger protein SNAI1 (Protein snail homolog) (Protein sna). 2Show
42MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 33Show
43TCEAL1TCAL1_HUMANTranscription elongation factor A protein-like 1 (TCEA-like protein 1)(Transcription elongation factor S-II protein-like 1) (Nuclearphosphoprotein p21/SIIR). 2Show
44RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show