Regulatory Network in Protein Phosphorylation
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Kinase: GSK3B glycogen synthase kinase 3 beta

Group: CMGC      Family: GSK      

Description: glycogen synthase kinase 3 beta

Gene Symbol: GSK3B

Synonyms: -

UniprotKB/SwissProt: GSK3B_HUMAN (P49841)

Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.

Subcellular Localization:

Protein Domain:
PDB:1GNG

The substrate proteins of kinase GSK3B

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 2Show
2ACLYACLY_HUMANATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme). 2Show
3CABYRCABYR_HUMANCalcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Testis-specific calcium-binding protein CBP86)(Fibrousheathin-2) (FSP-2) (Fibrousheathin II) (Cancer/testis antigen88) (CT88). 2Show
4CDH1CADH1_HUMANEpithelial cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1)(CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. 1Show
5CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 1Show
6CCND3CCND3_HUMANG1/S-specific cyclin-D3. 1Show
7CCNE1CCNE1_HUMANG1/S-specific cyclin-E1. 3Show
8CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
9CDX2CDX2_HUMANHomeobox protein CDX-2 (Caudal-type homeobox protein 2) (CDX-3). 4Show
10CEBPACEBPA_HUMANCCAAT/enhancer-binding protein alpha (C/EBP alpha). 2Show
11CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
12CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 1Show
13CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 8Show
14CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 2Show
15DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 3Show
16EIF2B5EI2BE_HUMANTranslation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon). 3Show
17ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 4Show
18FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 1Show
19GYS1GYS1_HUMANGlycogen [starch] synthase, muscle (EC 2.4.1.11). 7Show
20HNRPDHNRPD_HUMANHeterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich elementRNA-binding protein 1). 2Show
21PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 2Show
22MCL1MCL1_HUMANInduced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) (mcl1/EAT). 2Show
23MITFMITF_HUMANMicrophthalmia-associated transcription factor. 2Show
24MKI67IPMK67I_HUMANMKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolarprotein interacting with the FHA domain of pKI-67) (hNIFK) (Nucleolarphosphoprotein Nopp34). 2Show
25MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 3Show
26MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 2Show
27NACANACA_HUMANNascent polypeptide-associated complex subunit alpha (NAC-alpha)(Alpha-NAC) (Hom s 2.02). 2Show
28NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 5Show
29NOTCH2NOTC2_HUMANNeurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)[Contains: Notch 2 extracellular truncation; Notch 2 intracellulardomain]. 4Show
30TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
31PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 4Show
32PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
33DPYSL3Q6DEN2_HUMANDPYSL3 protein. 3Show
34RCAN1RCAN1_HUMANCalcipressin-1 (Regulator of calcineurin 1) (Down syndrome criticalregion protein 1) (Myocyte-enriched calcineurin-interacting protein 1)(MCIP1) (Adapt78). 2Show
35RAP1GAPRPGP1_HUMANRap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP). 1Show
36SNAI1SNAI_HUMANZinc finger protein SNAI1 (Protein snail homolog) (Protein sna). 2Show
37MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 31Show
38RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show



The substrate proteins of kinase family GSK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 2Show
2ACLYACLY_HUMANATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme). 4Show
3CABYRCABYR_HUMANCalcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Testis-specific calcium-binding protein CBP86)(Fibrousheathin-2) (FSP-2) (Fibrousheathin II) (Cancer/testis antigen88) (CT88). 2Show
4CDH1CADH1_HUMANEpithelial cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1)(CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. 1Show
5CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 2Show
6CCND3CCND3_HUMANG1/S-specific cyclin-D3. 1Show
7CCNE1CCNE1_HUMANG1/S-specific cyclin-E1. 4Show
8CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 1Show
9CDX2CDX2_HUMANHomeobox protein CDX-2 (Caudal-type homeobox protein 2) (CDX-3). 4Show
10CEBPACEBPA_HUMANCCAAT/enhancer-binding protein alpha (C/EBP alpha). 2Show
11CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 2Show
12CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 2Show
13CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 11Show
14CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 2Show
15DPYSL2DPYL2_HUMANDihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3). 3Show
16EIF2B5EI2BE_HUMANTranslation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon). 6Show
17ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 4Show
18FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 2Show
19GYS1GYS1_HUMANGlycogen [starch] synthase, muscle (EC 2.4.1.11). 7Show
20HNRPDHNRPD_HUMANHeterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich elementRNA-binding protein 1). 2Show
21HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 2Show
22PPP1R2P1IPP2L_HUMANProtein phosphatase inhibitor 2-like protein 1 (Protein phosphatase 1,regulatory subunit 2 pseudogene 1). 1Show
23PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 3Show
24JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 2Show
25MCL1MCL1_HUMANInduced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) (mcl1/EAT). 4Show
26MITFMITF_HUMANMicrophthalmia-associated transcription factor. 3Show
27MKI67IPMK67I_HUMANMKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolarprotein interacting with the FHA domain of pKI-67) (hNIFK) (Nucleolarphosphoprotein Nopp34). 2Show
28MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 3Show
29MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 2Show
30MYLKMYLK_HUMANMyosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK)(Telokin) (Kinase-related protein) (KRP). 1Show
31NACANACA_HUMANNascent polypeptide-associated complex subunit alpha (NAC-alpha)(Alpha-NAC) (Hom s 2.02). 2Show
32NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 5Show
33NOTCH2NOTC2_HUMANNeurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)[Contains: Notch 2 extracellular truncation; Notch 2 intracellulardomain]. 4Show
34TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
35PPP1R3APPR3A_HUMANProtein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1glycogen-associated regulatory subunit) (Protein phosphatase type-1glycogen targeting subunit). 2Show
36PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 4Show
37PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 2Show
38DPYSL3Q6DEN2_HUMANDPYSL3 protein. 3Show
39RCAN1RCAN1_HUMANCalcipressin-1 (Regulator of calcineurin 1) (Down syndrome criticalregion protein 1) (Myocyte-enriched calcineurin-interacting protein 1)(MCIP1) (Adapt78). 3Show
40RAP1GAPRPGP1_HUMANRap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP). 1Show
41SNAI1SNAI_HUMANZinc finger protein SNAI1 (Protein snail homolog) (Protein sna). 2Show
42MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 33Show
43TCEAL1TCAL1_HUMANTranscription elongation factor A protein-like 1 (TCEA-like protein 1)(Transcription elongation factor S-II protein-like 1) (Nuclearphosphoprotein p21/SIIR). 2Show
44RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show