Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: Erk2(MAPK1) mitogen-activated protein kinase 1

Group: CMGC      Family: MAPK      Subfamily: ERK1

Description: mitogen-activated protein kinase 1

Gene Symbol: MAPK1

Synonyms: ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk

UniprotKB/SwissProt: MK01_HUMAN (P28482)

Function: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).

Subcellular Localization:

Protein Domain:
PDB:1PME

The substrate proteins of kinase Erk2(MAPK1)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SH3BP53BP5_HUMANSH3 domain-binding protein 5 (SH3 domain-binding protein thatpreferentially associates with BTK). 2Show
2EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 6Show
3EIF4EBP24EBP2_HUMANEukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2)(eIF4E-binding protein 2). 1Show
4APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 1Show
5APBB1APBB1_HUMANAmyloid beta A4 precursor protein-binding family B member 1 (Fe65protein). 4Show
6ARRB1ARRB1_HUMANBeta-arrestin-1 (Arrestin beta 1). 1Show
7ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 4Show
8ATN1ATN1_HUMANAtrophin-1 (Dentatorubral-pallidoluysian atrophy protein). 1Show
9BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 1Show
10BCL2BCL2_HUMANApoptosis regulator Bcl-2. 1Show
11BCL2L11BIM_HUMANBcl-2-like protein 11 (Bcl2-interacting mediator of cell death). 1Show
12CAPN2CAN2_HUMANCalpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 largesubunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2). 1Show
13CASP3CASP3_HUMANCaspase-3 precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteineprotease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1)(SCA-1) [Contains: Caspase-3 subunit p17; Caspase-3 subunit p12]. 1Show
14CASP8CASP8_HUMANCaspase-8 precursor (EC 3.4.22.61) (CASP-8) (ICE-like apoptoticprotease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologousICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteineprotease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8subunit p18; Caspase-8 subunit p10]. 1Show
15CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
16CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 4Show
17CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 2Show
18CEBPACEBPA_HUMANCCAAT/enhancer-binding protein alpha (C/EBP alpha). 1Show
19CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 1Show
20CEP55CEP55_HUMANCentrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer6). 4Show
21RCSD1CPZIP_HUMANCapz-interacting protein (Protein kinase substrate CapZIP) (RCSDdomain-containing protein 1). 1Show
22CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
23GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 2Show
24DAPK1DAPK1_HUMANDeath-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1). 2Show
25DUSP16DUS16_HUMANDual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 7) (MAP kinasephosphatase 7) (MKP-7). 2Show
26DUSP1DUS1_HUMANDual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16)(MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphataseCL100) (Dual specificity protein phosphatase hVH1). 5Show
27DUSP6DUS6_HUMANDual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 3) (MAP kinasephosphatase 3) (MKP-3) (Dual specificity protein phosphatase PYST1). 3Show
28EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 1Show
29EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 1Show
30ELK1ELK1_HUMANETS domain-containing protein Elk-1. 8Show
31ERFERF_HUMANETS domain-containing transcription factor ERF (Ets2 repressorfactor). 9Show
32ESPL1ESPL1_HUMANSeparin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extraspindle poles-like 1 protein). 1Show
33ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
34ETV6ETV6_HUMANTranscription factor ETV6 (ETS-related protein Tel1) (Tel) (ETStranslocation variant 6). 1Show
35FOSFOS_HUMANProto-oncogene protein c-fos (Cellular oncogene fos) (G0/G1 switchregulatory protein 7). 5Show
36GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 8Show
37GAB2GAB2_HUMANGRB2-associated-binding protein 2 (Growth factor receptor boundprotein 2-associated protein 2) (GRB2-associated binder 2) (pp100). 1Show
38NR3C1GCR_HUMANGlucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group Cmember 1). 1Show
39GORASP2GORS2_HUMANGolgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stackingprotein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6). 1Show
40GRB10GRB10_HUMANGrowth factor receptor-bound protein 10 (GRB10 adaptor protein)(Insulin receptor-binding protein GRB-IR). 6Show
41GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 1Show
42HBP1HBP1_HUMANHMG box-containing protein 1 (HMG box transcription factor 1) (Highmobility group box transcription factor 1). 1Show
43HNF4AHNF4A_HUMANHepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factorHNF-4) (Nuclear receptor subfamily 2 group A member 1) (Transcriptionfactor 14). 1Show
44HNRPKHNRPK_HUMANHeterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformationup-regulated nuclear protein) (TUNP). 2Show
45IER3IEX1_HUMANRadiation-inducible immediate-early gene IEX-1 (Immediate earlyprotein GLY96) (Immediate early response 3 protein) (PACAP-responsivegene 1 protein) (Protein PRG1) (Differentiation-dependent gene 2protein) (Protein DIF-2). 1Show
46IL16IL16_HUMANInterleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor)(LCF). 1Show
47IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 2Show
48MAPK8IP1JIP1_HUMANC-jun-amino-terminal kinase-interacting protein 1 (JNK-interactingprotein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1)(IB-1) (Mitogen-activated protein kinase 8-interacting protein 1). 2Show
49JUNBJUNB_HUMANTranscription factor jun-B. 1Show
50KRT8K2C8_HUMANKeratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8)(K8). 2Show
51KHDRBS1KHDR1_HUMANKH domain-containing, RNA-binding, signal transduction-associatedprotein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68kDa protein) (Sam68) (p68). 4Show
52RPS6KA1KS6A1_HUMANRibosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1)(RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a)(MAPKAPK1A). 3Show
53RPS6KA4KS6A4_HUMANRibosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6kinase 4) (Ribosomal protein kinase B) (RSKB). 5Show
54RPS6KA5KS6A5_HUMANRibosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6kinase 5) (RSK-like protein kinase) (RSKL). 6Show
55LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 2Show
56LIFRLIFR_HUMANLeukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R)(CD118 antigen). 2Show
57LIPELIPS_HUMANHormone-sensitive lipase (EC 3.1.1.79) (HSL). 1Show
58MAPKAPK2MAPK2_HUMANMAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activatedprotein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2). 5Show
59MAPKAPK5MAPK5_HUMANMAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activatedprotein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated proteinkinase). 1Show
60MBPMBP_HUMANMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membraneencephalitogenic protein). 4Show
61MCL1MCL1_HUMANInduced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) (mcl1/EAT). 2Show
62MED1MED1_HUMANMediator of RNA polymerase II transcription subunit 1 (Mediatorcomplex subunit 1) (Peroxisome proliferator-activated receptor-bindingprotein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroidreceptor-interacting protein 2) (TRIP-2) (p53 regulatory proteinRB18A) (Vitamin D receptor-interacting protein complex componentDRIP205) (Activator-recruited cofactor 205 kDa component) (ARC205). 3Show
63MEF2AMEF2A_HUMANMyocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1). 4Show
64MEF2CMEF2C_HUMANMyocyte-specific enhancer factor 2C. 2Show
65MAPK1MK01_HUMANMitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). 3Show
66MAPK12MK12_HUMANMitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated proteinkinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38gamma). 1Show
67MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 3Show
68MYBMYB_HUMANMyb proto-oncogene protein (C-myb). 1Show
69MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 1Show
70NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 2Show
71NCOA1NCOA1_HUMANNuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroidreceptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (Renalcarcinoma antigen NY-REN-52). 4Show
72NDE1NDE1_HUMANNuclear distribution protein nudE homolog 1 (NudE). 2Show
73NDEL1NDEL1_HUMANNuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1). 2Show
74PPP1R9BNEB2_HUMANNeurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1regulatory subunit 9B). 1Show
75NFATC4NFAC4_HUMANNuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4)(T-cell transcription factor NFAT3) (NF-AT3). 3Show
76NEFHNFH_HUMANNeurofilament heavy polypeptide (NF-H) (Neurofilament triplet Hprotein) (200 kDa neurofilament protein). 3Show
77NR4A1NR4A1_HUMANNuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptorHMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). 1Show
78TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
79PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
80PAK1PAK1_HUMANSerine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activatedkinase 1) (PAK-1) (p65-PAK) (Alpha-PAK). 2Show
81PAK6PAK6_HUMANSerine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activatedkinase 6) (PAK-6) (PAK-5). 1Show
82PITPNM1PITM1_HUMANMembrane-associated phosphatidylinositol transfer protein 1(Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinaldegeneration B homolog). 2Show
83PPARAPPARA_HUMANPeroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclearreceptor subfamily 1 group C member 1). 2Show
84PPARGPPARG_HUMANPeroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclearreceptor subfamily 1 group C member 3). 2Show
85PPARGC1APRGC1_HUMANPeroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (PGC-1-alpha)(Ligand effect modulator 6). 3Show
86PGRPRGR_HUMANProgesterone receptor (PR) (Nuclear receptor subfamily 3 group Cmember 3). 1Show
87PTPN7PTN7_HUMANTyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48)(Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosinephosphatase) (HEPTP). 2Show
88PTPRRPTPRR_HUMANReceptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48)(Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase). 1Show
89CADPYR1_HUMANCAD protein [Includes: Glutamine-dependent carbamoyl-phosphatesynthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2);Dihydroorotase (EC 3.5.2.3)]. 2Show
90jdp2Q8WYK2_HUMANJun dimerization protein 2 (Jun dimerization protein 2, isoformCRA_a). 1Show
91SH2BQ9NRF2_HUMANSH2-B beta signaling protein (Putative uncharacterized proteinDKFZp727I201). 1Show
92RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 5Show
93RGS19RGS19_HUMANRegulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP). 3Show
94POLR2ARPB1_HUMANDNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6) (RNApolymerase II subunit B1) (DNA-directed RNA polymerase II subunit A)(DNA-directed RNA polymerase III largest subunit). 1Show
95RPS3RS3_HUMAN40S ribosomal protein S3. 1Show
96RXRARXRA_HUMANRetinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclearreceptor subfamily 2 group B member 1). 2Show
97SAKS1SAKS1_HUMANSAPK substrate protein 1 (UBA/UBX 33.3 kDa protein). 1Show
98SLC9A1SL9A1_HUMANSodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solutecarrier family 9 member 1) (Na(+)/H(+) antiporter, amiloride-sensitive) (APNH). 9Show
99SMAD1SMAD1_HUMANMothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1). 7Show
100SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 3Show
101SMAD3SMAD3_HUMANMothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3). 6Show
102SMAD4SMAD4_HUMANMothers against decapentaplegic homolog 4 (SMAD 4) (Mothers againstDPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4). 1Show
103SNTA1SNTA1_HUMANAlpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidiccomponent 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1)(TACIP1) (Syntrophin-1). 2Show
104SOS1SOS1_HUMANSon of sevenless homolog 1 (SOS-1). 10Show
105SP1SP1_HUMANTranscription factor Sp1. 4Show
106SREBF1SRBP1_HUMANSterol regulatory element-binding protein 1 (SREBP-1) (Sterolregulatory element-binding transcription factor 1) [Contains:Processed sterol regulatory element-binding protein 1]. 2Show
107SREBF2SRBP2_HUMANSterol regulatory element-binding protein 2 (SREBP-2) (Sterolregulatory element-binding transcription factor 2) [Contains:Processed sterol regulatory element-binding protein 2]. 2Show
108STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 1Show
109STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show
110NR5A1STF1_HUMANSteroidogenic factor 1 (STF-1) (SF-1) (Nuclear receptor subfamily 5group A member 1) (Adrenal 4-binding protein) (Steroid hormonereceptor Ad4BP) (Fushi tarazu factor homolog 1). 1Show
111STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 2Show
112MAP3K7IP1TAB1_HUMANMitogen-activated protein kinase kinase kinase 7-interacting protein 1(TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein1). 3Show
113MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 6Show
114RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show
115TCF3TFE2_HUMANTranscription factor E2-alpha (Immunoglobulin enhancer-binding factorE12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulintranscription factor 1) (Transcription factor ITF-1) (Kappa-E2-bindingfactor). 1Show
116THRBTHB_HUMANThyroid hormone receptor beta (Nuclear receptor subfamily 1 group Amember 2). 1Show
117TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alphaisozyme). 5Show
118TSC2TSC2_HUMANTuberin (Tuberous sclerosis 2 protein). 3Show
119ZFP36TTP_HUMANTristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36)(Protein TIS11A) (TIS11) (Growth factor-inducible nuclear proteinNUP475) (G0/G1 switch regulatory protein 24). 1Show
120UBTFUBF1_HUMANNucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1)(Autoantigen NOR-90). 4Show
121ZNHIT1ZNHI1_HUMANZinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet). 1Show



The substrate proteins of kinase family ERK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 1Show
2EIF4EBP24EBP2_HUMANEukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2)(eIF4E-binding protein 2). 1Show
3ADAM17ADA17_HUMANADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinasedomain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snakevenom-like protease) (CD156b antigen). 1Show
4ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2). 1Show
5ARRB1ARRB1_HUMANBeta-arrestin-1 (Arrestin beta 1). 1Show
6BCL2L11BIM_HUMANBcl-2-like protein 11 (Bcl2-interacting mediator of cell death). 1Show
7CALD1CALD1_HUMANCaldesmon (CDM). 1Show
8CAPN2CAN2_HUMANCalpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 largesubunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2). 1Show
9CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
10CCDC6CCDC6_HUMANCoiled-coil domain-containing protein 6 (Protein H4) (Papillarythyroid carcinoma-encoded protein). 1Show
11CEBPACEBPA_HUMANCCAAT/enhancer-binding protein alpha (C/EBP alpha). 1Show
12CEBPBCEBPB_HUMANCCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF-IL6) (Transcription factor 5). 1Show
13PDE6GCNRG_HUMANRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterasesubunit gamma (EC 3.1.4.17) (GMP-PDE gamma). 1Show
14GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 3Show
15DUSP1DUS1_HUMANDual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16)(MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphataseCL100) (Dual specificity protein phosphatase hVH1). 2Show
16DUSP6DUS6_HUMANDual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 3) (MAP kinasephosphatase 3) (MKP-3) (Dual specificity protein phosphatase PYST1). 1Show
17EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 1Show
18ELK1ELK1_HUMANETS domain-containing protein Elk-1. 2Show
19ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 1Show
20ETS1ETS1_HUMANProtein C-ets-1 (p54). 1Show
21ETV6ETV6_HUMANTranscription factor ETV6 (ETS-related protein Tel1) (Tel) (ETStranslocation variant 6). 2Show
22FOSFOS_HUMANProto-oncogene protein c-fos (Cellular oncogene fos) (G0/G1 switchregulatory protein 7). 3Show
23GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 7Show
24GAB2GAB2_HUMANGRB2-associated-binding protein 2 (Growth factor receptor boundprotein 2-associated protein 2) (GRB2-associated binder 2) (pp100). 2Show
25GRB10GRB10_HUMANGrowth factor receptor-bound protein 10 (GRB10 adaptor protein)(Insulin receptor-binding protein GRB-IR). 2Show
26GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 1Show
27HNRPKHNRPK_HUMANHeterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformationup-regulated nuclear protein) (TUNP). 1Show
28HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 1Show
29HSPB8HSPB8_HUMANHeat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (Smallstress protein-like protein HSP22) (E2-induced gene 1 protein)(Protein kinase H11). 4Show
30IL16IL16_HUMANInterleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor)(LCF). 1Show
31IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show
32KRT8K2C8_HUMANKeratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8)(K8). 3Show
33RPS6KA3KS6A3_HUMANRibosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2)(RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAPkinase-activated protein kinase 1b) (MAPKAPK1B). 1Show
34RPS6KA5KS6A5_HUMANRibosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6kinase 5) (RSK-like protein kinase) (RSKL). 6Show
35LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 2Show
36LIFRLIFR_HUMANLeukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R)(CD118 antigen). 1Show
37LIPELIPS_HUMANHormone-sensitive lipase (EC 3.1.1.79) (HSL). 1Show
38MAZMAZ_HUMANMyc-associated zinc finger protein (MAZI) (Purine-bindingtranscription factor) (Pur-1) (ZF87) (ZIF87). 1Show
39MBPMBP_HUMANMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membraneencephalitogenic protein). 1Show
40MCL1MCL1_HUMANInduced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) (mcl1/EAT). 1Show
41MED1MED1_HUMANMediator of RNA polymerase II transcription subunit 1 (Mediatorcomplex subunit 1) (Peroxisome proliferator-activated receptor-bindingprotein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroidreceptor-interacting protein 2) (TRIP-2) (p53 regulatory proteinRB18A) (Vitamin D receptor-interacting protein complex componentDRIP205) (Activator-recruited cofactor 205 kDa component) (ARC205). 3Show
42MAPK3MK03_HUMANMitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase)(MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase). 2Show
43MKNK1MKNK1_HUMANMAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1)(MAP kinase signal-integrating kinase 1) (Mnk1). 2Show
44MYBMYB_HUMANMyb proto-oncogene protein (C-myb). 1Show
45NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 2Show
46NFATC4NFAC4_HUMANNuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4)(T-cell transcription factor NFAT3) (NF-AT3). 1Show
47PLCB1PLCB1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154). 2Show
48PPARAPPARA_HUMANPeroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclearreceptor subfamily 1 group C member 1). 2Show
49PGRPRGR_HUMANProgesterone receptor (PR) (Nuclear receptor subfamily 3 group Cmember 3). 1Show
50PTPN7PTN7_HUMANTyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48)(Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosinephosphatase) (HEPTP). 2Show
51PTPRRPTPRR_HUMANReceptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48)(Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase). 1Show
52CADPYR1_HUMANCAD protein [Includes: Glutamine-dependent carbamoyl-phosphatesynthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2);Dihydroorotase (EC 3.5.2.3)]. 1Show
53SH2BQ9NRF2_HUMANSH2-B beta signaling protein (Putative uncharacterized proteinDKFZp727I201). 1Show
54RCAN1RCAN1_HUMANCalcipressin-1 (Regulator of calcineurin 1) (Down syndrome criticalregion protein 1) (Myocyte-enriched calcineurin-interacting protein 1)(MCIP1) (Adapt78). 1Show
55RGS19RGS19_HUMANRegulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP). 1Show
56POLR2ARPB1_HUMANDNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6) (RNApolymerase II subunit B1) (DNA-directed RNA polymerase II subunit A)(DNA-directed RNA polymerase III largest subunit). 1Show
57RRN3RRN3_HUMANRNA polymerase I-specific transcription initiation factor RRN3(Transcription initiation factor IA) (TIF-IA). 1Show
58RPS3RS3_HUMAN40S ribosomal protein S3. 1Show
59RXRARXRA_HUMANRetinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclearreceptor subfamily 2 group B member 1). 1Show
60SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 7Show
61SMAD4SMAD4_HUMANMothers against decapentaplegic homolog 4 (SMAD 4) (Mothers againstDPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4). 1Show
62SP1SP1_HUMANTranscription factor Sp1. 4Show
63SPIBSPIB_HUMANTranscription factor Spi-B. 2Show
64SREBF1SRBP1_HUMANSterol regulatory element-binding protein 1 (SREBP-1) (Sterolregulatory element-binding transcription factor 1) [Contains:Processed sterol regulatory element-binding protein 1]. 2Show
65SREBF2SRBP2_HUMANSterol regulatory element-binding protein 2 (SREBP-2) (Sterolregulatory element-binding transcription factor 2) [Contains:Processed sterol regulatory element-binding protein 2]. 2Show
66CTTNSRC8_HUMANSrc substrate cortactin (Amplaxin) (Oncogene EMS1). 2Show
67STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 1Show
68STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show
69STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 1Show
70STMN2STMN2_HUMANStathmin-2 (Protein SCG10) (Superior cervical ganglion-10 protein). 2Show
71SYN3SYN3_HUMANSynapsin-3 (Synapsin III). 1Show
72TAL1TAL1_HUMANT-cell acute lymphocytic leukemia protein 1 (TAL-1) (Stem cellprotein) (T-cell leukemia/lymphoma protein 5). 2Show
73TCF3TFE2_HUMANTranscription factor E2-alpha (Immunoglobulin enhancer-binding factorE12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulintranscription factor 1) (Transcription factor ITF-1) (Kappa-E2-bindingfactor). 1Show
74THRBTHB_HUMANThyroid hormone receptor beta (Nuclear receptor subfamily 1 group Amember 2). 1Show
75TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alphaisozyme). 5Show
76UBTFUBF1_HUMANNucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1)(Autoantigen NOR-90). 4Show