|Group: CMGC Family: MAPK Subfamily: JNK|
Description: mitogen-activated protein kinase 10
Gene Symbol: MAPK10
Synonyms: FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK
UniprotKB/SwissProt: MK10_HUMAN (P53779)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity (By similarity).
Subcellular Localization: Cytoplasm.