|Group: CMGC Family: MAPK Subfamily: ERK1|
Description: mitogen-activated protein kinase 3
Gene Symbol: MAPK3
Synonyms: ERK1, HS44KDAP, HUMKER1A, MGC20180, P44ERK1, P44MAPK, PRKM3
UniprotKB/SwissProt: MK03_HUMAN (P27361)
Function: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).