Regulatory Network in Protein Phosphorylation
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Kinase: Erk5(MAPK7) mitogen-activated protein kinase 7

Group: CMGC      Family: MAPK      Subfamily: ERK5

Description: mitogen-activated protein kinase 7

Gene Symbol: MAPK7

Synonyms: BMK1, ERK4, ERK5, PRKM7

UniprotKB/SwissProt: MK07_HUMAN (Q13164)

Function: MEK5 and ERK5 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase Erk5(MAPK7)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 2Show
2ETS1ETS1_HUMANProtein C-ets-1 (p54). 2Show
3MEF2AMEF2A_HUMANMyocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1). 6Show
4MEF2CMEF2C_HUMANMyocyte-specific enhancer factor 2C. 2Show
5MEF2DMEF2D_HUMANMyocyte-specific enhancer factor 2D. 1Show
6MAP2K5MP2K5_HUMANDual specificity mitogen-activated protein kinase kinase 5(EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5). 4Show
7RXRARXRA_HUMANRetinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclearreceptor subfamily 2 group B member 1). 2Show
8SGK1SGK1_HUMANSerine/threonine-protein kinase Sgk1 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 1). 2Show



The substrate proteins of kinase family ERK5

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 2Show
2ETS1ETS1_HUMANProtein C-ets-1 (p54). 2Show
3MEF2AMEF2A_HUMANMyocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1). 6Show
4MEF2CMEF2C_HUMANMyocyte-specific enhancer factor 2C. 2Show
5MEF2DMEF2D_HUMANMyocyte-specific enhancer factor 2D. 1Show
6MAP2K5MP2K5_HUMANDual specificity mitogen-activated protein kinase kinase 5(EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5). 4Show
7RXRARXRA_HUMANRetinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclearreceptor subfamily 2 group B member 1). 2Show
8SGK1SGK1_HUMANSerine/threonine-protein kinase Sgk1 (EC 2.7.11.1)(Serum/glucocorticoid-regulated kinase 1). 2Show