Regulatory Network in Protein Phosphorylation
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Kinase: p38d(MAPK13) mitogen-activated protein kinase 13

Group: CMGC      Family: MAPK      Subfamily: p38

Description: mitogen-activated protein kinase 13

Gene Symbol: MAPK13

Synonyms: MGC99536, PRKM13, SAPK4, p38delta

UniprotKB/SwissProt: MK13_HUMAN (O15264)

Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase p38d(MAPK13)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1RCSD1CPZIP_HUMANCapz-interacting protein (Protein kinase substrate CapZIP) (RCSDdomain-containing protein 1). 1Show
2EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 3Show
3STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 2Show



The substrate proteins of kinase family p38

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1SH3BP53BP5_HUMANSH3 domain-binding protein 5 (SH3 domain-binding protein thatpreferentially associates with BTK). 5Show
2EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
3ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 7Show
4BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 1Show
5CASP3CASP3_HUMANCaspase-3 precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteineprotease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1)(SCA-1) [Contains: Caspase-3 subunit p17; Caspase-3 subunit p12]. 1Show
6CASP8CASP8_HUMANCaspase-8 precursor (EC 3.4.22.61) (CASP-8) (ICE-like apoptoticprotease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologousICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteineprotease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8subunit p18; Caspase-8 subunit p10]. 1Show
7CDX2CDX2_HUMANHomeobox protein CDX-2 (Caudal-type homeobox protein 2) (CDX-3). 4Show
8RCSD1CPZIP_HUMANCapz-interacting protein (Protein kinase substrate CapZIP) (RCSDdomain-containing protein 1). 1Show
9CREB1CREB1_HUMANcAMP response element-binding protein (CREB). 1Show
10DDIT3DDIT3_HUMANDNA damage-inducible transcript 3 (DDIT-3) (Growth arrest and DNA-damage-inducible protein GADD153) (C/EBP-homologous protein) (CHOP). 4Show
11EEF2KEF2K_HUMANElongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). 6Show
12ELK1ELK1_HUMANETS domain-containing protein Elk-1. 4Show
13ELK3ELK3_HUMANETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS-related protein ERP) (SRF accessory protein 2) (SAP-2). 1Show
14ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
15ETV6ETV6_HUMANTranscription factor ETV6 (ETS-related protein Tel1) (Tel) (ETStranslocation variant 6). 1Show
16HBP1HBP1_HUMANHMG box-containing protein 1 (HMG box transcription factor 1) (Highmobility group box transcription factor 1). 1Show
17HNF4AHNF4A_HUMANHepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factorHNF-4) (Nuclear receptor subfamily 2 group A member 1) (Transcriptionfactor 14). 2Show
18JUNBJUNB_HUMANTranscription factor jun-B. 3Show
19KRT8K2C8_HUMANKeratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8)(K8). 2Show
20KHDRBS1KHDR1_HUMANKH domain-containing, RNA-binding, signal transduction-associatedprotein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68kDa protein) (Sam68) (p68). 2Show
21RPS6KA4KS6A4_HUMANRibosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6kinase 4) (Ribosomal protein kinase B) (RSKB). 10Show
22RPS6KA5KS6A5_HUMANRibosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6kinase 5) (RSK-like protein kinase) (RSKL). 6Show
23MAPKAPK2MAPK2_HUMANMAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activatedprotein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2). 10Show
24MAPKAPK5MAPK5_HUMANMAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activatedprotein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated proteinkinase). 3Show
25MAXMAX_HUMANProtein max (Myc-associated factor X). 2Show
26MEF2AMEF2A_HUMANMyocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1). 7Show
27MEF2CMEF2C_HUMANMyocyte-specific enhancer factor 2C. 5Show
28MAPK12MK12_HUMANMitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated proteinkinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38gamma). 2Show
29CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 1Show
30NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 2Show
31NCOA3NCOA3_HUMANNuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormonereceptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associatedcoactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1)(Steroid receptor coactivator protein 3) (SRC-3) (CBP-interactingprotein) (pCIP). 4Show
32NFATC4NFAC4_HUMANNuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4)(T-cell transcription factor NFAT3) (NF-AT3). 4Show
33TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 1Show
34PLA2G4APA24A_HUMANCytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA)[Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]. 1Show
35PAK6PAK6_HUMANSerine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activatedkinase 6) (PAK-6) (PAK-5). 1Show
36PPARGC1APRGC1_HUMANPeroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (PGC-1-alpha)(Ligand effect modulator 6). 6Show
37PTPN7PTN7_HUMANTyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48)(Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosinephosphatase) (HEPTP). 2Show
38jdp2Q8WYK2_HUMANJun dimerization protein 2 (Jun dimerization protein 2, isoformCRA_a). 1Show
39ZFYVE20RBNS5_HUMANRabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5)(Zinc finger FYVE domain-containing protein 20) (110 kDa protein). 1Show
40SAKS1SAKS1_HUMANSAPK substrate protein 1 (UBA/UBX 33.3 kDa protein). 1Show
41SLC9A1SL9A1_HUMANSodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solutecarrier family 9 member 1) (Na(+)/H(+) antiporter, amiloride-sensitive) (APNH). 8Show
42SMAD3SMAD3_HUMANMothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3). 2Show
43SNTA1SNTA1_HUMANAlpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidiccomponent 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1)(TACIP1) (Syntrophin-1). 4Show
44STAT4STAT4_HUMANSignal transducer and activator of transcription 4. 1Show
45STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 2Show
46MAP3K7IP1TAB1_HUMANMitogen-activated protein kinase kinase kinase 7-interacting protein 1(TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein1). 3Show
47MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 10Show
48RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show
49ZNHIT1ZNHI1_HUMANZinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet). 1Show