|Group: CMGC Family: MAPK Subfamily: nmo|
Description: nemo-like kinase
Gene Symbol: NLK
Synonyms: DKFZp761G1211, FLJ21033
UniprotKB/SwissProt: NLK_HUMAN (Q9UBE8)
Function: Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta- catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity).
Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity).