Regulatory Network in Protein Phosphorylation
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Kinase: p38a(MAPK14) mitogen-activated protein kinase 14

Group: CMGC      Family: MAPK      Subfamily: p38

Description: mitogen-activated protein kinase 14

Gene Symbol: MAPK14

Synonyms: CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA

UniprotKB/SwissProt: MK14_HUMAN (Q16539)

Function: Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).

Protein Domain:
PDB:1A9U

The substrate proteins of kinase p38a(MAPK14)

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No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF4EBP14EBP1_HUMANEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I). 3Show
2ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 7Show
3BADBAD_HUMANBcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein). 1Show
4CASP3CASP3_HUMANCaspase-3 precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteineprotease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1)(SCA-1) [Contains: Caspase-3 subunit p17; Caspase-3 subunit p12]. 1Show
5CASP8