Regulatory Network in Protein Phosphorylation
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Kinase: p38a(MAPK14) mitogen-activated protein kinase 14

Group: CMGC      Family: MAPK      Subfamily: p38

Description: mitogen-activated protein kinase 14

Gene Symbol: MAPK14

Synonyms: CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA

UniprotKB/SwissProt: MK14_HUMAN (Q16539)

Function: Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).

Protein Domain:
PDB:1A9U