|Group: CMGC Family: MAPK Subfamily: p38|
Description: mitogen-activated protein kinase 12
Gene Symbol: MAPK12
Synonyms: ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3
UniprotKB/SwissProt: MK12_HUMAN (P53778)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
Subcellular Localization: Cytoplasm. Mitochondrion. Note=Mitochondrial when associated with SH3BP5.