Regulatory Network in Protein Phosphorylation
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Kinase: p38g(MAPK12) mitogen-activated protein kinase 12

Group: CMGC      Family: MAPK      Subfamily: p38

Description: mitogen-activated protein kinase 12

Gene Symbol: MAPK12

Synonyms: ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3

UniprotKB/SwissProt: MK12_HUMAN (P53778)

Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.

Subcellular Localization: Cytoplasm. Mitochondrion. Note=Mitochondrial when associated with SH3BP5.

Protein Domain:
PDB:1CM8