Regulatory Network in Protein Phosphorylation
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Kinase: AurA aurora kinase A

Group: Other      Family: Aur      

Description: aurora kinase A

Gene Symbol: AURKA

Synonyms: AIK, ARK1, AURA, AURORA2, BTAK, MGC34538, STK15, STK6, STK7

UniprotKB/SwissProt: STK6_HUMAN (O14965)

Function: May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Maybe involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression.

Subcellular Localization: Centrosome. Spindle. Note=Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.

Protein Domain:
PDB:1MQ4

The substrate proteins of kinase AurA

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 2Show
2CENPACENPA_HUMANHistone H3-like centromeric protein A (Centromere protein A) (CENP-A)(Centromere autoantigen A). 2Show
3CPEB1CPEB1_HUMANCytoplasmic polyadenylation element-binding protein 1 (CPE-bindingprotein 1) (CPE-BP1) (hCPEB-1) (h-CEBP). 1Show
4HIST1H3AH31_HUMANHistone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l). 1Show
5KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
6LATS2LATS2_HUMANSerine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumorsuppressor homolog 2) (Serine/threonine-protein kinase kp