Regulatory Network in Protein Phosphorylation
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Kinase: AurC aurora kinase C

Group: Other      Family: Aur      

Description: aurora kinase C

Gene Symbol: AURKC

Synonyms: AIE2, AIK3, AurC, STK13, aurora-C

UniprotKB/SwissProt: AURKC_HUMAN (Q9UQB9)

Function: May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis.

Subcellular Localization: Centrosome. Note=Localized to centrosome from anaphase to cytokinesis.

Protein Domain:

The substrate proteins of kinase family Aur

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1AURKBAURKB_HUMANSerine/threonine-protein kinase 12 (EC (Aurora-B) (Aurora-and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1). 1Show
2BIRC5BIRC5_HUMANBaculoviral IAP repeat-containing protein 5 (Apoptosis inhibitorsurvivin) (Apoptosis inhibitor 4). 1Show
3BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 2Show
4CENPACENPA_HUMANHistone H3-like centromeric protein A (Centromere protein A) (CENP-A)(Centromere autoantigen A). 3Show
5CPEB1CPEB1_HUMANCytoplasmic polyadenylation element-binding protein 1 (CPE-bindingprotein 1) (CPE-BP1) (hCPEB-1) (h-CEBP). 1Show
7GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 3Show
8HIST1H3AH31_HUMANHistone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l). 2Show
9H3F3AH33_HUMANHistone H3.3. 2Show
10INCENPINCE_HUMANInner centromere protein. 6Show
11KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
12KIF2CKIF2C_HUMANKinesin-like protein KIF2C (Mitotic centromere-associated kinesin)(MCAK) (Kinesin-like protein 6). 1Show
13LATS2LATS2_HUMANSerine/threonine-protein kinase LATS2 (EC (Large tumorsuppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinasephosphorylated during mitosis protein) (Warts-like kinase). 2Show
14MBD3MBD3_HUMANMethyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3). 2Show
15CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC (Dual specificityphosphatase Cdc25B). 2Show
16NSUN2NSUN2_HUMANtRNA (cytosine-5-)-methyltransferase NSUN2 (EC (EC 2.1.1.-)(NOL1/NOP2/Sun domain family member 2) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)(Substrate of AIM1/Aurora kinase B). 1Show
17TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
18RACGAP1RGAP1_HUMANRac GTPase-activating protein 1 (MgcRacGAP). 9Show
19AURKASTK6_HUMANSerine/threonine-protein kinase 6 (EC (Aurora kinase A)(Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1)(Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase). 14Show
20VIMVIME_HUMANVimentin. 1Show