Regulatory Network in Protein Phosphorylation
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Kinase: AurB aurora kinase B

Group: Other      Family: Aur      

Description: aurora kinase B

Gene Symbol: AURKB

Synonyms: AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5

UniprotKB/SwissProt: AURKB_HUMAN (Q96GD4)

Function: May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis.

Subcellular Localization: Nucleus. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid- body.

Protein Domain:

The substrate proteins of kinase AurB

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1AURKBAURKB_HUMANSerine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora-and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1). 1Show
2BIRC5BIRC5_HUMANBaculoviral IAP repeat-containing protein 5 (Apoptosis inhibitorsurvivin) (Apoptosis inhibitor 4). 1Show
3CENPACENPA_HUMANHistone H3-like centromeric protein A (Centromere protein A) (CENP-A)(Centromere autoantigen A). 3Show
4DESDESM_HUMANDesmin. 5Show
5GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 3Show
6HIST1H3AH31_HUMANHistone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l). 2Show
7H3F3AH33_HUMANHistone H3.3. 2Show
8INCENPINCE_HUMANInner centromere protein. 6Show
9KIF2CKIF2C_HUMANKinesin-like protein KIF2C (Mitotic centromere-associated kinesin)(MCAK) (Kinesin-like protein 6). 1Show
10NSUN2NSUN2_HUMANtRNA (cytosine-5-)-methyltransferase NSUN2 (EC 2.1.1.29) (EC 2.1.1.-)(NOL1/NOP2/Sun domain family member 2) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)(Substrate of AIM1/Aurora kinase B). 1Show
11RACGAP1RGAP1_HUMANRac GTPase-activating protein 1 (MgcRacGAP). 9Show
12VIMVIME_HUMANVimentin. 1Show



The substrate proteins of kinase family Aur

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1AURKBAURKB_HUMANSerine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora-and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1). 1Show
2BIRC5BIRC5_HUMANBaculoviral IAP repeat-containing protein 5 (Apoptosis inhibitorsurvivin) (Apoptosis inhibitor 4). 1Show
3BRCA1BRCA1_HUMANBreast cancer type 1 susceptibility protein (RING finger protein 53). 2Show
4CENPACENPA_HUMANHistone H3-like centromeric protein A (Centromere protein A) (CENP-A)(Centromere autoantigen A). 3Show
5CPEB1CPEB1_HUMANCytoplasmic polyadenylation element-binding protein 1 (CPE-bindingprotein 1) (CPE-BP1) (hCPEB-1) (h-CEBP). 1Show
6DESDESM_HUMANDesmin. 5Show
7GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 3Show
8HIST1H3AH31_HUMANHistone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l). 2Show
9H3F3AH33_HUMANHistone H3.3. 2Show
10INCENPINCE_HUMANInner centromere protein. 6Show
11KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
12KIF2CKIF2C_HUMANKinesin-like protein KIF2C (Mitotic centromere-associated kinesin)(MCAK) (Kinesin-like protein 6). 1Show
13LATS2LATS2_HUMANSerine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumorsuppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinasephosphorylated during mitosis protein) (Warts-like kinase). 2Show
14MBD3MBD3_HUMANMethyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3). 2Show
15CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B). 2Show
16NSUN2NSUN2_HUMANtRNA (cytosine-5-)-methyltransferase NSUN2 (EC 2.1.1.29) (EC 2.1.1.-)(NOL1/NOP2/Sun domain family member 2) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)(Substrate of AIM1/Aurora kinase B). 1Show
17TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
18RACGAP1RGAP1_HUMANRac GTPase-activating protein 1 (MgcRacGAP). 9Show
19AURKASTK6_HUMANSerine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora kinase A)(Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1)(Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase). 14Show
20VIMVIME_HUMANVimentin. 1Show