Regulatory Network in Protein Phosphorylation
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Kinase: CaMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha

Group: Other      Family: CAMKK      Subfamily: Meta

Description: calcium/calmodulin-dependent protein kinase kinase 1, alpha

Gene Symbol: CAMKK1

Synonyms: CAMKKA, DKFZp761M0423, MGC34095

UniprotKB/SwissProt: KKCC1_HUMAN (Q8N5S9)

Function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).

Protein Domain:

The substrate proteins of kinase CaMKK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PRKAA1AAPK1_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-1(EC (AMPK alpha-1 chain). 1Show
2AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 1Show
3CAMK1KCC1A_HUMANCalcium/calmodulin-dependent protein kinase type 1 (EC (CaMkinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha). 1Show
4CAMK1DKCC1D_HUMANCalcium/calmodulin-dependent protein kinase type 1D (EC kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta)(CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK). 3Show
5CAMK4KCC4_HUMANCalcium/calmodulin-dependent protein kinase type IV (EC kinase-GR) (CaMK IV). 1Show