Regulatory Network in Protein Phosphorylation
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Kinase: CaMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta

Group: Other      Family: CAMKK      Subfamily: Meta

Description: calcium/calmodulin-dependent protein kinase kinase 2, beta

Gene Symbol: CAMKK2

Synonyms: CAMKK, CAMKKB, KIAA0787, MGC15254

UniprotKB/SwissProt: KKCC2_HUMAN (Q96RR4)

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 (By similarity).

Subcellular Localization: Cytoplasm (By similarity).

Protein Domain:

The substrate proteins of kinase CaMKK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PRKAA1AAPK1_HUMAN5'-AMP-activated protein kinase catalytic subunit alpha-1(EC (AMPK alpha-1 chain). 1Show
2CAMK1KCC1A_HUMANCalcium/calmodulin-dependent protein kinase type 1 (EC (CaMkinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha). 2Show
3CAMK1DKCC1D_HUMANCalcium/calmodulin-dependent protein kinase type 1D (EC kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta)(CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK). 1Show
4CAMK4KCC4_HUMANCalcium/calmodulin-dependent protein kinase type IV (EC kinase-GR) (CaMK IV). 1Show