Regulatory Network in Protein Phosphorylation
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Kinase: CK2a1 casein kinase 2, alpha 1 polypeptide

Group: CMGC      Family: CK2      

Description: casein kinase 2, alpha 1 polypeptide

Gene Symbol: CSNK2A1

Synonyms: CK2A1, CKII, CKII alpha

UniprotKB/SwissProt: CSK21_HUMAN (P68400)

Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.

Subcellular Localization:

Protein Domain:
PDB:1JWH

The substrate proteins of kinase CK2a1