Regulatory Network in Protein Phosphorylation
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Kinase: IKKa conserved helix-loop-helix ubiquitous kinase

Group: Other      Family: IKK      

Description: conserved helix-loop-helix ubiquitous kinase

Gene Symbol: CHUK

Synonyms: IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16

UniprotKB/SwissProt: IKKA_HUMAN (O15111)

Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B- regulated promoters during inflammatory responses triggered by cytokines.

Subcellular Localization: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.

Protein Domain:

The substrate proteins of kinase IKKa

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 1Show
2NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 4Show
3NFKBIBIKBB_HUMANNF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta)(IkappaBbeta) (IkB-beta) (IkB-B) (Thyroid receptor-interacting protein9) (TRIP-9) (TR-interacting protein 9). 2Show
4IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 2Show
5NCOA3NCOA3_HUMANNuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormonereceptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associatedcoactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1)(Steroid receptor coactivator protein 3) (SRC-3) (CBP-interactingprotein) (pCIP). 1Show
6NCOR2NCOR2_HUMANNuclear receptor corepressor 2 (N-CoR2) (Silencing mediator ofretinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-,retinoic-acid-receptor-associated corepressor) (T3 receptor-associating factor) (TRAC) (CTG repeat protein 26) (SMAP270). 1Show
7NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 7Show
8NFKB2NFKB2_HUMANNuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit]. 1Show
9RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show



The substrate proteins of kinase family IKK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 1Show
2FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 1Show
3NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 7Show
4NFKBIBIKBB_HUMANNF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta)(IkappaBbeta) (IkB-beta) (IkB-B) (Thyroid receptor-interacting protein9) (TRIP-9) (TR-interacting protein 9). 4Show
5IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 30Show
6IRF3IRF3_HUMANInterferon regulatory factor 3 (IRF-3). 2Show
7IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 20Show
8IRS2IRS2_HUMANInsulin receptor substrate 2 (IRS-2). 5Show
9NCOA3NCOA3_HUMANNuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormonereceptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associatedcoactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1)(Steroid receptor coactivator protein 3) (SRC-3) (CBP-interactingprotein) (pCIP). 2Show
10NCOR2NCOR2_HUMANNuclear receptor corepressor 2 (N-CoR2) (Silencing mediator ofretinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-,retinoic-acid-receptor-associated corepressor) (T3 receptor-associating factor) (TRAC) (CTG repeat protein 26) (SMAP270). 1Show
11IKBKGNEMO_HUMANNF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier)(Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinasesubunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkBkinase-associated protein 1) (IKKAP1) (FIP-3). 6Show
12NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 9Show
13NFKB2NFKB2_HUMANNuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit]. 1Show
14RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show