Regulatory Network in Protein Phosphorylation
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Kinase: TBK1 TANK-binding kinase 1

Group: Other      Family: IKK      

Description: TANK-binding kinase 1

Gene Symbol: TBK1

Synonyms: FLJ11330, NAK, T2K

UniprotKB/SwissProt: TBK1_HUMAN (Q9UHD2)

Function: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase TBK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 1Show
2IRF3IRF3_HUMANInterferon regulatory factor 3 (IRF-3). 1Show
3MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 7Show
4TUBBTBB5_HUMANTubulin beta chain (Tubulin beta-5 chain). 1Show
5RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show

The substrate proteins of kinase family IKK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CCND1CCND1_HUMANG1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). 1Show
2FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 1Show
3NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 7Show
4NFKBIBIKBB_HUMANNF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta)(IkappaBbeta) (IkB-beta) (IkB-B) (Thyroid receptor-interacting protein9) (TRIP-9) (TR-interacting protein 9). 4Show
5IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 30Show
6IRF3IRF3_HUMANInterferon regulatory factor 3 (IRF-3). 2Show
7IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 20Show
8IRS2IRS2_HUMANInsulin receptor substrate 2 (IRS-2). 5Show
9NCOA3NCOA3_HUMANNuclear receptor coactivator 3 (EC (NCoA-3) (Thyroid hormonereceptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associatedcoactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1)(Steroid receptor coactivator protein 3) (SRC-3) (CBP-interactingprotein) (pCIP). 2Show
10NCOR2NCOR2_HUMANNuclear receptor corepressor 2 (N-CoR2) (Silencing mediator ofretinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-,retinoic-acid-receptor-associated corepressor) (T3 receptor-associating factor) (TRAC) (CTG repeat protein 26) (SMAP270). 1Show
11IKBKGNEMO_HUMANNF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier)(Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinasesubunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkBkinase-associated protein 1) (IKKAP1) (FIP-3). 6Show
12NFKB1NFKB1_HUMANNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]. 9Show
13NFKB2NFKB2_HUMANNuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit]. 1Show
14RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show