Regulatory Network in Protein Phosphorylation
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Kinase: IRE1 endoplasmic reticulum to nucleus signalling 1

Group: Other      Family: IRE      

Description: endoplasmic reticulum to nucleus signalling 1

Gene Symbol: ERN1

Synonyms: FLJ30999, IRE1, IRE1P, MGC163277, MGC163279

UniprotKB/SwissProt: ERN1_HUMAN (O75460)

Function: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:2HZ6