|Group: Other Family: IRE |
Description: endoplasmic reticulum to nucleus signalling 1
Gene Symbol: ERN1
Synonyms: FLJ30999, IRE1, IRE1P, MGC163277, MGC163279
UniprotKB/SwissProt: ERN1_HUMAN (O75460)
Function: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.