Regulatory Network in Protein Phosphorylation
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Kinase: IRE2 endoplasmic reticulum to nucleus signalling 2

Group: Other      Family: IRE      

Description: endoplasmic reticulum to nucleus signalling 2

Gene Symbol: ERN2

Synonyms: IRE1b

UniprotKB/SwissProt: ERN2_HUMAN (Q76MJ5)

Function: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Domain: