|Group: Other Family: IRE |
Description: endoplasmic reticulum to nucleus signalling 2
Gene Symbol: ERN2
UniprotKB/SwissProt: ERN2_HUMAN (Q76MJ5)
Function: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.