Regulatory Network in Protein Phosphorylation
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Kinase: KIS U2AF homology motif (UHM) kinase 1

Group: Other      Family: KIS      

Description: U2AF homology motif (UHM) kinase 1

Gene Symbol: UHMK1

Synonyms: KIS, Kist

UniprotKB/SwissProt: UHMK1_HUMAN (Q8TAS1)

Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

Subcellular Localization: Nucleus. Note=Mostly nuclear (By similarity).

Protein Domain:

The substrate proteins of kinase KIS

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]. 1Show
2CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 2Show
3MBPMBP_HUMANMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membraneencephalitogenic protein). 1Show
4SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 1Show



The substrate proteins of kinase family KIS

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]. 1Show
2CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 2Show
3MBPMBP_HUMANMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membraneencephalitogenic protein). 1Show
4SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 1Show