Regulatory Network in Protein Phosphorylation
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Kinase: GAK cyclin G associated kinase

Group: Other      Family: NAK      Subfamily: GAK

Description: cyclin G associated kinase

Gene Symbol: GAK

Synonyms: FLJ40395, MGC99654

UniprotKB/SwissProt: GAK_HUMAN (O14976)

Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.

Subcellular Localization: Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion (Probable). Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focals adhesions.

Protein Domain: