|Group: Other Family: NAK Subfamily: GAK|
Description: cyclin G associated kinase
Gene Symbol: GAK
Synonyms: FLJ40395, MGC99654
UniprotKB/SwissProt: GAK_HUMAN (O14976)
Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Subcellular Localization: Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion (Probable). Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focals adhesions.