Regulatory Network in Protein Phosphorylation
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Kinase: HRI eukaryotic translation initiation factor 2-alpha kinase 1

Group: Other      Family: PEK      Subfamily: HRI

Description: eukaryotic translation initiation factor 2-alpha kinase 1

Gene Symbol: EIF2AK1

Synonyms: HRI, KIAA1369

UniprotKB/SwissProt: E2AK1_HUMAN (Q9BQI3)

Function: Mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51'. Protein synthesis is inhibited at the level of initiation (By similarity).

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase HRI

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 5Show



The substrate proteins of kinase family HRI

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 5Show