|Group: Other Family: PEK Subfamily: PEK|
Description: eukaryotic translation initiation factor 2-alpha kinase 3
Gene Symbol: EIF2AK3
Synonyms: DKFZp781H1925, PEK, PERK, WRS
UniprotKB/SwissProt: E2AK3_HUMAN (Q9NZJ5)
Function: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity).
Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.