Regulatory Network in Protein Phosphorylation
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Kinase: PEK eukaryotic translation initiation factor 2-alpha kinase 3

Group: Other      Family: PEK      Subfamily: PEK

Description: eukaryotic translation initiation factor 2-alpha kinase 3

Gene Symbol: EIF2AK3

Synonyms: DKFZp781H1925, PEK, PERK, WRS

UniprotKB/SwissProt: E2AK3_HUMAN (Q9NZJ5)

Function: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity).

Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Domain:

The substrate proteins of kinase PEK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 1Show



The substrate proteins of kinase family PEK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 1Show