Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: PKR eukaryotic translation initiation factor 2-alpha kinase 2

Group: Other      Family: PEK      Subfamily: PKR

Description: eukaryotic translation initiation factor 2-alpha kinase 2

Gene Symbol: EIF2AK2

Synonyms: EIF2AK1, MGC126524, PKR, PRKR

UniprotKB/SwissProt: E2AK2_HUMAN (P19525)

Function: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Subcellular Localization:

Protein Domain:
PDB:1QU6

The substrate proteins of kinase PKR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PPP2R5A2A5A_HUMANSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunitalpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit,B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, Bsubunit, R5 alpha isoform). 1Show
2EIF2AK2E2AK2_HUMANInterferon-induced, double-stranded RNA-activated protein kinase(EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase)(Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2Aprotein kinase 2) (Protein kinase RNA-activated) (PKR) (p68 kinase)(P1/eIF-2A protein kinase). 17Show
3EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 4Show
4NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 2Show
5TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show



The substrate proteins of kinase family PKR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1PPP2R5A2A5A_HUMANSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunitalpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit,B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, Bsubunit, R5 alpha isoform). 1Show
2EIF2AK2E2AK2_HUMANInterferon-induced, double-stranded RNA-activated protein kinase(EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase)(Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2Aprotein kinase 2) (Protein kinase RNA-activated) (PKR) (p68 kinase)(P1/eIF-2A protein kinase). 17Show
3EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 4Show
4NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 2Show
5TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show