Regulatory Network in Protein Phosphorylation
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Kinase: PLK1 polo-like kinase 1 (Drosophila)

Group: Other      Family: PLK      Subfamily: PLK1

Description: polo-like kinase 1 (Drosophila)

Gene Symbol: PLK1

Synonyms: PLK, STPK13

UniprotKB/SwissProt: PLK1_HUMAN (P53350)

Function: May be required for cell division and may have a role during G1 or S phase.

Subcellular Localization: Nucleus.

Protein Domain:
PDB:1Q4K

The substrate proteins of kinase PLK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ANAPC1ANC1_HUMANAnaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1)(Testis-specific gene 24 protein) (Mitotic checkpoint regulator). 10Show
2ANAPC4ANC4_HUMANAnaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4). 1Show
3ANAPC7APC7_HUMANAnaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7). 3Show
4BRCA2BRCA2_HUMANBreast cancer type 2 susceptibility protein (Fanconi anemia group D1protein). 3Show
5CCNB1CCNB1_HUMANG2/mitotic-specific cyclin-B1. 8Show
6CDC23CDC23_HUMANCell division cycle protein 23 homolog (Anaphase-promoting complexsubunit 8) (APC8) (Cyclosome subunit 8). 2Show
7CDC27CDC27_HUMANCell division cycle protein 27 homolog (CDC27Hs) (H-NUC). 6Show
8CEP55CEP55_HUMANCentrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer6). 2Show
9CHEK2CHK2_HUMANSerine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1). 4Show
10ECT2ECT2_HUMANProtein ECT2 (Epithelial cell-transforming sequence 2 oncogene). 1Show
11IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show
12CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 2Show
13NLPNLP_HUMANNinein-like protein. 4Show
14NPM1NPM_HUMANNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38). 3Show
15NUDCNUDC_HUMANNuclear migration protein nudC (Nuclear distribution protein Chomolog). 6Show
16PIN1PIN1_HUMANPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8)(Rotamase Pin1) (PPIase Pin1). 1Show
17PKMYT1PMYT1_HUMANMembrane-associated tyrosine- and threonine-specific cdc2-inhibitorykinase (EC 2.7.11.1) (Myt1 kinase). 6Show
18TPT1TCTP_HUMANTranslationally-controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) (Fortilin). 6Show
19WEE1WEE1_HUMANWee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). 2Show



The substrate proteins of kinase family PLK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ANAPC1ANC1_HUMANAnaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1)(Testis-specific gene 24 protein) (Mitotic checkpoint regulator). 10Show
2ANAPC4ANC4_HUMANAnaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4). 1Show
3ANAPC7APC7_HUMANAnaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7). 3Show
4BRCA2BRCA2_HUMANBreast cancer type 2 susceptibility protein (Fanconi anemia group D1protein). 3Show
5CCNB1CCNB1_HUMANG2/mitotic-specific cyclin-B1. 8Show
6CDC23CDC23_HUMANCell division cycle protein 23 homolog (Anaphase-promoting complexsubunit 8) (APC8) (Cyclosome subunit 8). 2Show
7CDC27CDC27_HUMANCell division cycle protein 27 homolog (CDC27Hs) (H-NUC). 6Show
8CEP55CEP55_HUMANCentrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer6). 2Show
9CHEK2CHK2_HUMANSerine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1). 4Show
10ECT2ECT2_HUMANProtein ECT2 (Epithelial cell-transforming sequence 2 oncogene). 1Show
11IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show
12CDC25CMPIP3_HUMANM-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25C). 2Show
13NLPNLP_HUMANNinein-like protein. 4Show
14NPM1NPM_HUMANNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38). 3Show
15NUDCNUDC_HUMANNuclear migration protein nudC (Nuclear distribution protein Chomolog). 6Show
16PIN1PIN1_HUMANPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8)(Rotamase Pin1) (PPIase Pin1). 1Show
17PKMYT1PMYT1_HUMANMembrane-associated tyrosine- and threonine-specific cdc2-inhibitorykinase (EC 2.7.11.1) (Myt1 kinase). 6Show
18TPT1TCTP_HUMANTranslationally-controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) (Fortilin). 6Show
19WEE1WEE1_HUMANWee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). 2Show