|Group: Other Family: TLK |
Description: tousled-like kinase 1
Gene Symbol: TLK1
Synonyms: KIAA0137, PKU-BETA
UniprotKB/SwissProt: TLK1_HUMAN (Q9UKI8)
Function: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Subcellular Localization: Nucleus.