Regulatory Network in Protein Phosphorylation
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Kinase: TLK1 tousled-like kinase 1

Group: Other      Family: TLK      

Description: tousled-like kinase 1

Gene Symbol: TLK1

Synonyms: KIAA0137, PKU-BETA

UniprotKB/SwissProt: TLK1_HUMAN (Q9UKI8)

Function: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Subcellular Localization: Nucleus.

Protein Domain: