Regulatory Network in Protein Phosphorylation
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Kinase: PBK PDZ binding kinase

Group: Other      Family: TOPK      

Description: PDZ binding kinase

Gene Symbol: PBK

Synonyms: FLJ14385, Nori-3, SPK, TOPK

UniprotKB/SwissProt: TOPK_HUMAN (Q96KB5)

Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Subcellular Localization:

Protein Domain: