|Group: Other Family: TOPK |
Description: PDZ binding kinase
Gene Symbol: PBK
Synonyms: FLJ14385, Nori-3, SPK, TOPK
UniprotKB/SwissProt: TOPK_HUMAN (Q96KB5)
Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.